TCF7
Information TCF7
- Description
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
- Full Name
transcription factor 7
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 41,385
- Non-redundant peaks
- 39,053
TF Classification
- Super Class
- Other all-alpha-helical DNA-binding domains
- Class
- High-mobility group (HMG) domain factors
- Familly
- TCF-7-related factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000081059
- UniProt
- P36402
- Genevisible
- P36402
- RefSeq
- NM_001134851
- Aliases
- TCF-1
Datasets Table for TCF7
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TCF7 | GM12878 | ENCODE | Homo sapiens | ENCSR501DKS | 10,895 | |||
| TCF7 | Hep-G2 | ENCODE | Homo sapiens | ENCSR444LIN | 22,878 | |||
| TCF7 | K-562 | ENCODE | Homo sapiens | ENCSR863KUB | 7,612 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |