SOX2

Information SOX2

Description

This intronless gene encodes a member of the SRY-related HMG-box (SOX) family of transcription factors involved in the regulation of embryonic development and in the determination of cell fate. The product of this gene is required for stem-cell maintenance in the central nervous system, and also regulates gene expression in the stomach. Mutations in this gene have been associated with optic nerve hypoplasia and with syndromic microphthalmia, a severe form of structural eye malformation. This gene lies within an intron of another gene called SOX2 overlapping transcript (SOX2OT). [provided by RefSeq, Jul 2008]

Full Name

SRY-box transcription factor 2

Source NCBI

ReMap Statistics

Datasets
20
Biotypes
13
Peaks
377,627
Non-redundant peaks
288,800

TF Classification

Super Class
Other all-alpha-helical DNA-binding domains
Class
High-mobility group (HMG) domain factors
Familly
SOX-related factors
Sub Familly
Group B

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000181449
UniProt
P48431
Genevisible
P48431
RefSeq
NM_003106
Aliases
ANOP3; MCOPS3
All peaks SOX2
Download BED file
Non redundant peaks SOX2
Download BED file
SEQUENCES SOX2
Download FASTA file
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Datasets Table for SOX2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SOX2 BJ INDUCED GEO Homo sapiens GSE36570 121,462
SOX2 glioma stem GEO Homo sapiens GSE67282 3,859
SOX2 hESC GEO Homo sapiens GSE18292 18,963
SOX2 hESC GEO Homo sapiens GSE69479 2,352
SOX2 HNSC GEO Homo sapiens GSE69479 74,636
SOX2 KYSE70 GEO Homo sapiens GSE46837 6,840
SOX2 RENVM GEO Homo sapiens GSE49404 38,149
SOX2 RENVM SHSOX2 GEO Homo sapiens GSE49404 4,497
SOX2 TT GEO Homo sapiens GSE46837 10,181
SOX2 H9 GEO Homo sapiens GSE46837 3,216
SOX2 hiPSC GEO Homo sapiens GSE56567 64,223
SOX2 hiPSC GEO Homo sapiens GSE67282 6,645
SOX2 hiPSC INHI GEO Homo sapiens GSE67282 3,238
SOX2 hiPSC KDP53 GEO Homo sapiens GSE67282 5,025
SOX2 hiPSC KDP53_INHI GEO Homo sapiens GSE67282 6,198
SOX2 hiPSC 3s2 GEO Homo sapiens GSE81899 879
SOX2 OSK GEO Homo sapiens GSE81899 1,237
SOX2 OSKM GEO Homo sapiens GSE81899 5,507
SOX2 OSvK GEO Homo sapiens GSE81899 263
SOX2 OSvKM GEO Homo sapiens GSE81899 257
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.