RFX1
Information RFX1
- Description
This gene encodes a member of the regulatory factor X (RFX) family of transcription factors, which are characterized by a winged-helix DNA-binding domain. The encoded transcription factor contains an N-terminal activation domain and a C-terminal repression domain, and may activate or repress target gene expression depending on cellular context. This transcription factor has been shown to regulate a wide variety of genes involved in immunity and cancer, including the MHC class II genes and genes that may be involved in cancer progression. This gene exhibits altered expression in glioblastoma and the autoimmune disease systemic lupus erythematosis (SLE). [provided by RefSeq, Jul 2016]
- Full Name
regulatory factor X1
- Source NCBI
ReMap Statistics
- Datasets
- 5
- Biotypes
- 3
- Peaks
- 90,460
- Non-redundant peaks
- 45,579
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Fork head / winged helix factors
- Familly
- RFX-related factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000132005
- UniProt
- P22670
- Genevisible
- P22670
- RefSeq
- NM_002918
- Aliases
- EF-C; EFC; RFX
Datasets Table for RFX1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| RFX1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR928API | 3,523 | |||
| RFX1 | K-562 | ENCODE | Homo sapiens | ENCSR041AXL | 17,904 | |||
| RFX1 | K-562 | ENCODE | Homo sapiens | ENCSR968GIB | 22,420 | |||
| RFX1 | MCF-7 | ENCODE | Homo sapiens | ENCSR066TET | 28,829 | |||
| RFX1 | MCF-7 | ENCODE | Homo sapiens | ENCSR788XNX | 17,784 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |