REST
Information REST
- Description
This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]
- Full Name
RE1 silencing transcription factor
- Source NCBI
ReMap Statistics
- Datasets
- 35
- Biotypes
- 21
- Peaks
- 710,632
- Non-redundant peaks
- 299,483
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- C2H2 zinc finger factors
- Familly
- Factors with multiple dispersed zinc fingers
- Sub Familly
- unclassified
Source TFClass
External IDs
- JASPAR
- MA0138
- Ensembl
- ENSG00000084093
- UniProt
- Q13127
- Genevisible
- Q13127
- RefSeq
- NM_001193508
- Aliases
- DFNA27; GINGF5; HGF5; NRSF; WT6; XBR
Datasets Table for REST
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
---|---|---|---|---|---|---|---|---|
REST | GM12878 | ENCODE | Homo sapiens | ENCSR000BGF | 8,691 | |||
REST | GM12878 | ENCODE | Homo sapiens | ENCSR000BQS | 20,703 | |||
REST | HEK293 | ENCODE | Homo sapiens | ENCSR896UBV | 27,224 | |||
REST | hepatocyte | ENA | Homo sapiens | ERP000395 | 1,186 | |||
REST | Ishikawa | ENCODE | Homo sapiens | ENCSR000BUU | 13,561 | |||
REST | liver | ENCODE | Homo sapiens | ENCSR867WPH | 41,981 | |||
REST | liver | ENCODE | Homo sapiens | ENCSR893QWP | 27,993 | |||
REST | neural | ENCODE | Homo sapiens | ENCSR000BTV | 57,836 | |||
REST | PFSK1 | ENCODE | Homo sapiens | ENCSR000BJP | 7,954 | |||
REST | PFSK1 | ENCODE | Homo sapiens | ENCSR000BOX | 20,958 | |||
Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
Showing 1 to 10 of 35 entries