RB1
Information RB1
- Description
The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
- Full Name
RB transcriptional corepressor 1
- Source NCBI
ReMap Statistics
- Datasets
- 7
- Biotypes
- 4
- Peaks
- 111,094
- Non-redundant peaks
- 69,524
TF Classification
- Super Class
- Unknown
- Class
- Unknown
- Familly
- Unknown
- Sub Familly
- Unknown
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000139687
- UniProt
- P06400
- Genevisible
- P06400
- RefSeq
- NM_000321
- Aliases
- OSRC; PPP1R130; RB; p105-Rb; pRb; pp110
Datasets Table for RB1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| RB1 | GM12878 | ENCODE | Homo sapiens | ENCSR785OKZ | 41,597 | |||
| RB1 | GM12878 | ENCODE | Homo sapiens | ENCSR916BOH | 2,969 | |||
| RB1 | K-562 | ENCODE | Homo sapiens | ENCSR506CVF | 19,876 | |||
| RB1 | K-562 | ENCODE | Homo sapiens | ENCSR670JDQ | 25,380 | |||
| RB1 | fibroblast | SENESCENT | GEO | Homo sapiens | GSE19898 | 104 | ||
| RB1 | MCF-7 | siGFP | GEO | Homo sapiens | GSE98728 | 11,617 | ||
| RB1 | MCF-7 | siH1 | GEO | Homo sapiens | GSE98728 | 9,551 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |