POU5F1
Information POU5F1
- Description
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewing's sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013]
- Full Name
POU class 5 homeobox 1
- Source NCBI
ReMap Statistics
- Datasets
- 24
- Biotypes
- 15
- Peaks
- 539,925
- Non-redundant peaks
- 369,430
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Homeo domain factors
- Familly
- POU domain factors
- Sub Familly
- POU5 (Oct-3/4-like factors)
Source TFClass
External IDs
- JASPAR
- MA1115
- Ensembl
- ENSG00000237582
- UniProt
- Q01860
- Genevisible
- Q01860
- RefSeq
- NM_001173531
- Aliases
- MGC22487; OCT3; OCT4; OTF-3; OTF3; OTF4; Oct-3; Oct-4
Datasets Table for POU5F1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| POU5F1 | fetal | testis | GEO | Homo sapiens | GSE100639 | 118,928 | ||
| POU5F1 | hESC | ENCODE | Homo sapiens | ENCSR264RJX | 10,900 | |||
| POU5F1 | WA09 | GEO | Homo sapiens | GSE105028 | 6,604 | |||
| POU5F1 | WA09 | heat-shock | GEO | Homo sapiens | GSE105028 | 5,242 | ||
| POU5F1 | K-562 | ENCODE | Homo sapiens | ENCSR364SNE | 5,505 | |||
| POU5F1 | WA01 | ENCODE | Homo sapiens | ENCSR000BMU | 4,512 | |||
| POU5F1 | WA01 | 3IL | ENA | Homo sapiens | ERP004238 | 32,792 | ||
| POU5F1 | neuron | bipolar_doxy_4d | ENCODE | Homo sapiens | ENCSR362VCG | 3,232 | ||
| POU5F1 | BGO3 | GEO | Homo sapiens | GSE21614 | 75,386 | |||
| POU5F1 | BJ | GEO | Homo sapiens | GSE36570 | 769 | |||
| POU5F1 | BJ | INDUCED | GEO | Homo sapiens | GSE36570 | 50,804 | ||
| POU5F1 | hESC | GEO | Homo sapiens | GSE17917 | 89 | |||
| POU5F1 | hESC | GEO | Homo sapiens | GSE20650 | 268 | |||
| POU5F1 | hESC | NAIVE | GEO | Homo sapiens | GSE69646 | 76,522 | ||
| POU5F1 | hESC | PRIMED | GEO | Homo sapiens | GSE69646 | 29,056 | ||
| POU5F1 | NCCIT | GEO | Homo sapiens | GSE36134 | 5,455 | |||
| POU5F1 | NCCIT | SNF5 | GEO | Homo sapiens | GSE36134 | 36,360 | ||
| POU5F1 | BJ1-hTERT | GEO | Homo sapiens | GSE92491 | 19,919 | |||
| POU5F1 | hiPSC | GEO | Homo sapiens | GSE56567 | 31,141 | |||
| POU5F1 | hiPSC | 3s2 | GEO | Homo sapiens | GSE81899 | 7,936 | ||
| POU5F1 | OSK | GEO | Homo sapiens | GSE81899 | 5,954 | |||
| POU5F1 | OSKM | GEO | Homo sapiens | GSE81899 | 10,367 | |||
| POU5F1 | OSvK | GEO | Homo sapiens | GSE81899 | 682 | |||
| POU5F1 | OSvKM | GEO | Homo sapiens | GSE81899 | 1,502 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |