NR1H2
Information NR1H2
- Description
The liver X receptors, LXRA (NR1H3; MIM 602423) and LXRB, form a subfamily of the nuclear receptor superfamily and are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. The inducible LXRA is highly expressed in liver, adrenal gland, intestine, adipose tissue, macrophages, lung, and kidney, whereas LXRB is ubiquitously expressed. Ligand-activated LXRs form obligate heterodimers with retinoid X receptors (RXRs; see MIM 180245) and regulate expression of target genes containing LXR response elements (summary by Korf et al., 2009 [PubMed 19436111]).[supplied by OMIM, Jan 2010]
- Full Name
nuclear receptor subfamily 1 group H member 2
- Source NCBI
ReMap Statistics
- Datasets
- 2
- Biotypes
- 1
- Peaks
- 53,627
- Non-redundant peaks
- 41,353
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- Nuclear receptors with C4 zinc fingers
- Familly
- Thyroid hormone receptor-related factors (NR1)
- Sub Familly
- LXR (NR1H)
Source TFClass
External IDs
- JASPAR
- MA0115
- Ensembl
- ENSG00000131408
- UniProt
- P55055
- Genevisible
- P55055
- RefSeq
- NM_001256647
- Aliases
- LXR-b; LXRB; LXRb; NER; NER-I; RIP15; UNR
Datasets Table for NR1H2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NR1H2 | HT29 | GW3965_2H | GEO | Homo sapiens | GSE77039 | 15,625 | ||
| NR1H2 | HT29 | GW3965_48H | GEO | Homo sapiens | GSE77039 | 38,002 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |