MYCN
Information MYCN
- Description
This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
- Full Name
MYCN proto-oncogene, bHLH transcription factor
- Source NCBI
ReMap Statistics
- Datasets
- 26
- Biotypes
- 13
- Peaks
- 770,155
- Non-redundant peaks
- 443,532
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- Myc / Max factors
Source TFClass
External IDs
- JASPAR
- MA0104
- Ensembl
- ENSG00000134323
- UniProt
- P04198
- Genevisible
- P04198
- RefSeq
- NM_001293228
- Aliases
- MODED; MYCNOT; N-myc; NMYC; ODED; bHLHe37
Datasets Table for MYCN
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MYCN | SH-SY5Y | ENA | Homo sapiens | ERP013415 | 399 | |||
| MYCN | SH-SY5Y | OVERMYCN_24H | ENA | Homo sapiens | ERP013415 | 132 | ||
| MYCN | SH-SY5Y | OVERMYCN_48H | ENA | Homo sapiens | ERP013415 | 86 | ||
| MYCN | SMS-KCN | ENA | Homo sapiens | ERP013415 | 145 | |||
| MYCN | SMS-KCNR | ENA | Homo sapiens | ERP013415 | 117 | |||
| MYCN | BE2C | GEO | Homo sapiens | GSE72640 | 658 | |||
| MYCN | BE2C | GEO | Homo sapiens | GSE80151 | 41,892 | |||
| MYCN | Kelly | GEO | Homo sapiens | GSE80151 | 8,013 | |||
| MYCN | NGP | GEO | Homo sapiens | GSE80151 | 17,875 | |||
| MYCN | RH4 | GEO | Homo sapiens | GSE83726 | 27,092 | |||
| MYCN | SH-EP | 2h | GEO | Homo sapiens | GSE80151 | 866 | ||
| MYCN | SH-EP | 6h | GEO | Homo sapiens | GSE80151 | 1,862 | ||
| MYCN | SHEP-21N | GEO | Homo sapiens | GSE80151 | 64,226 | |||
| MYCN | SHEP-21N | 24h | GEO | Homo sapiens | GSE80151 | 21,263 | ||
| MYCN | SHEP-21N | DOX_0H | GEO | Homo sapiens | GSE80151 | 22,668 | ||
| MYCN | SHEP-21N | DOX_24H | GEO | Homo sapiens | GSE80151 | 18,430 | ||
| MYCN | SK-N-BE2-C | GEO | Homo sapiens | GSE80151 | 41,377 | |||
| MYCN | MYCN-3 | high | GEO | Homo sapiens | GSE83317 | 1,026 | ||
| MYCN | MYCN-3 | low | GEO | Homo sapiens | GSE83317 | 20,175 | ||
| MYCN | Kelly | GEO | Homo sapiens | GSE94782 | 41,832 | |||
| MYCN | Kelly | GEO | Homo sapiens | GSE94822 | 65,700 | |||
| MYCN | NGP | GEO | Homo sapiens | GSE94782 | 322,633 | |||
| MYCN | NB-1643 | GEO | Homo sapiens | GSE94782 | 17,160 | |||
| MYCN | SK-N-BE2-C | GEO | Homo sapiens | GSE94822 | 34,528 | |||
| MYCN | IMR-5 | CD532 | GEO | Homo sapiens | GSE78957 | 6,846 | ||
| MYCN | IMR-5 | DMSO | GEO | Homo sapiens | GSE78957 | 6,568 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |