MYC
Information MYC
- Description
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. [provided by RefSeq, Aug 2017]
- Full Name
MYC proto-oncogene, bHLH transcription factor
- Source NCBI
ReMap Statistics
- Datasets
- 86
- Biotypes
- 46
- Peaks
- 1,951,131
- Non-redundant peaks
- 786,376
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- Myc / Max factors
Source TFClass
External IDs
- JASPAR
- MA0147
- Ensembl
- ENSG00000136997
- UniProt
- P01106
- Genevisible
- P01106
- RefSeq
- NM_001354870
- Aliases
- MRTL; MYCC; bHLHe39; c-Myc
Datasets Table for MYC
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MYC | endothelial | umbilical-vein | ENCODE | Homo sapiens | ENCSR000DLU | 34,441 | ||
| MYC | GM12878 | ENCODE | Homo sapiens | ENCSR000DKU | 8,035 | |||
| MYC | LCL | ENA | Homo sapiens | ERP004110 | 390,988 | |||
| MYC | NB4 | ENCODE | Homo sapiens | ENCSR000EHR | 7,750 | |||
| MYC | A-549 | ENCODE | Homo sapiens | ENCSR000DYC | 11,891 | |||
| MYC | Hep-G2 | ENCODE | Homo sapiens | ENCSR000DLR | 9,809 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000DLZ | 23,383 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000EGJ | 50,579 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000EGS | 25,810 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000EZU | 22,692 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000EZV | 11,762 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000FAG | 20,037 | |||
| MYC | K-562 | ENCODE | Homo sapiens | ENCSR000FAZ | 6,559 | |||
| MYC | MCF-10A | ENCODE | Homo sapiens | ENCSR000DOM | 20,215 | |||
| MYC | MCF-10A | ENCODE | Homo sapiens | ENCSR000DOS | 54,910 | |||
| MYC | MCF-7 | ENCODE | Homo sapiens | ENCSR000DMJ | 162,930 | |||
| MYC | MCF-7 | ENCODE | Homo sapiens | ENCSR000DMM | 102,371 | |||
| MYC | MCF-7 | ENCODE | Homo sapiens | ENCSR000DMP | 6,137 | |||
| MYC | MCF-7 | ENCODE | Homo sapiens | ENCSR000DMQ | 48,512 | |||
| MYC | P493-6 | Dpy30-shRNA | GEO | Homo sapiens | GSE101853 | 31,019 | ||
| MYC | P493-6 | scramble-shRNA | GEO | Homo sapiens | GSE101853 | 36,807 | ||
| MYC | WA01 | ENCODE | Homo sapiens | ENCSR000DLI | 997 | |||
| MYC | WA01 | ENCODE | Homo sapiens | ENCSR000EBY | 7,973 | |||
| MYC | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000DLN | 4,113 | |||
| MYC | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000EZD | 42,524 | |||
| MYC | BE2C | SHCTR | GEO | Homo sapiens | GSE70098 | 15,592 | ||
| MYC | BE2C | SHWDR5 | GEO | Homo sapiens | GSE70098 | 13,785 | ||
| MYC | BJ | GEO | Homo sapiens | GSE36570 | 11,599 | |||
| MYC | BJ | INDUCED | GEO | Homo sapiens | GSE36570 | 31,997 | ||
| MYC | BL41 | GEO | Homo sapiens | GSE30726 | 20,623 | |||
| MYC | BLUE1 | GEO | Homo sapiens | GSE30726 | 6,010 | |||
| MYC | breast | primary | GEO | Homo sapiens | GSE66252 | 2,041 | ||
| MYC | CA46 | GEO | Homo sapiens | GSE30726 | 1,171 | |||
| MYC | CD34 | GEO | Homo sapiens | GSE85488 | 63,549 | |||
| MYC | CUTLL1 | GEO | Homo sapiens | GSE90716 | 5,517 | |||
| MYC | GP5D | GEO | Homo sapiens | GSE51234 | 22,935 | |||
| MYC | GP5D | SIRAD21 | GEO | Homo sapiens | GSE51234 | 8,804 | ||
| MYC | H128 | GEO | Homo sapiens | GSE41105 | 40,310 | |||
| MYC | HeLa | GEO | Homo sapiens | GSE44672 | 11,356 | |||
| MYC | hESC | GEO | Homo sapiens | GSE17917 | 4 | |||
| MYC | HFF | OHT | GEO | Homo sapiens | GSE65544 | 5,940 | ||
| MYC | HFF | OHT_SHBPTF | GEO | Homo sapiens | GSE65544 | 5,292 | ||
| MYC | IMEC | GEO | Homo sapiens | GSE70001 | 2,040 | |||
| MYC | IMEC | GEO | Homo sapiens | GSE86412 | 4,931 | |||
| MYC | IMEC | MYC | GEO | Homo sapiens | GSE86412 | 4,379 | ||
| MYC | Jurkat | GEO | Homo sapiens | GSE83777 | 25,374 | |||
| MYC | LNCaP | MYC | GEO | Homo sapiens | GSE73994 | 32,252 | ||
| MYC | LoVo | PHASEM | GEO | Homo sapiens | GSE51290 | 1,091 | ||
| MYC | LoVo | PHASES | GEO | Homo sapiens | GSE51290 | 7,118 | ||
| MYC | LS174T | BI8622 | GEO | Homo sapiens | GSE59223 | 4,248 | ||
| MYC | LS174T | DMSO | GEO | Homo sapiens | GSE59223 | 924 | ||
| MYC | PAVE | GEO | Homo sapiens | GSE47152 | 6,129 | |||
| MYC | Raji | GEO | Homo sapiens | GSE30726 | 11,591 | |||
| MYC | Ramos | GEO | Homo sapiens | GSE30726 | 6,326 | |||
| MYC | U2OS | GEO | Homo sapiens | GSE44672 | 5,454 | |||
| MYC | U2OS | Doxy | GEO | Homo sapiens | GSE44672 | 25,358 | ||
| MYC | U2OS | Doxy | GEO | Homo sapiens | GSE77328 | 18,020 | ||
| MYC | U2OS | EtOH | GEO | Homo sapiens | GSE77328 | 10,271 | ||
| MYC | U2OS | HA-OmoMYCwt_Doxy | GEO | Homo sapiens | GSE77328 | 18,486 | ||
| MYC | U2OS | HA-OmoMYCwt_EtOH | GEO | Homo sapiens | GSE77328 | 11,398 | ||
| MYC | U2OS | GEO | Homo sapiens | GSE77356 | 5,706 | |||
| MYC | U2OS | Doxy | GEO | Homo sapiens | GSE77356 | 37,551 | ||
| MYC | U2OS | SHMYC | GEO | Homo sapiens | GSE77356 | 6,679 | ||
| MYC | U2OS | SHRCTR | GEO | Homo sapiens | GSE77356 | 30,852 | ||
| MYC | DLD-1 | MYC-activated | GEO | Homo sapiens | GSE117240 | 12,374 | ||
| MYC | HT-1080 | GEO | Homo sapiens | GSE86504 | 12,836 | |||
| MYC | HUVEC-C | GEO | Homo sapiens | GSE93030 | 305 | |||
| MYC | MDA-MB-231 | GEO | Homo sapiens | GSE48602 | 64 | |||
| MYC | MDA-MB-453 | DHT | GEO | Homo sapiens | GSE45201 | 19,486 | ||
| MYC | NCI-H2171 | GEO | Homo sapiens | GSE36354 | 63,909 | |||
| MYC | NCI-H2171 | GEO | Homo sapiens | GSE41105 | 5,044 | |||
| MYC | P493-6 | GEO | Homo sapiens | GSE36354 | 3,936 | |||
| MYC | P493-6 | CMYC_1H | GEO | Homo sapiens | GSE36354 | 7,256 | ||
| MYC | P493-6 | CMYC_24H | GEO | Homo sapiens | GSE36354 | 5,933 | ||
| MYC | P493-6 | GEO | Homo sapiens | GSE42262 | 6,818 | |||
| MYC | P493-6 | SHCTR | GEO | Homo sapiens | GSE60223 | 18,358 | ||
| MYC | P493-6 | SHTERC | GEO | Homo sapiens | GSE60223 | 16,887 | ||
| MYC | P493-6 | SHTERT | GEO | Homo sapiens | GSE60223 | 1,913 | ||
| MYC | MM1-S | DMSO | GEO | Homo sapiens | GSE36354 | 34,921 | ||
| MYC | U-87MG | GEO | Homo sapiens | GSE36354 | 23,709 | |||
| MYC | MM1-S | JQ1 | GEO | Homo sapiens | GSE42161 | 3,390 | ||
| MYC | GEN2-2 | GEO | Homo sapiens | GSE70275 | 10,210 | |||
| MYC | OSKM | GEO | Homo sapiens | GSE81899 | 248 | |||
| MYC | HCT-116 | GEO | Homo sapiens | GSE86556 | 6,324 | |||
| MYC | MDA-MB-231 | GEO | Homo sapiens | GSE95303 | 11,556 | |||
| MYC | iMEC | GEO | Homo sapiens | GSE86412 | 4,931 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |