MAX

Information MAX

Description: The protein encoded by this gene is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It is able to form homodimers and heterodimers with other family members, which include Mad, Mxi1 and Myc. Myc is an oncoprotein implicated in cell proliferation, differentiation and apoptosis. The homodimers and heterodimers compete for a common DNA target site (the E box) and rearrangement among these dimer forms provides a complex system of transcriptional regulation. Mutations of this gene have been reported to be associated with hereditary pheochromocytoma. A pseudogene of this gene is located on the long arm of chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]
Full Name: MYC associated factor X; Source NCBI

ReMap Statistics

Datasets: 31
Biotypes: 20
Peaks: 1,488,940
Non-redundant peaks: 496,635

TF Classification

Super Class: Basic domains
Class: Basic helix-loop-helix factors (bHLH)
Familly: bHLH-ZIP factors
Sub Familly: Myc / Max factors; Source TFClass

External IDs

JASPAR: MA0059
Ensembl: ENSG00000125952
UniProt: P61244
Genevisible: P61244
RefSeq: NM_001271068
Aliases: bHLHd4

External links

All peaks MAX

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Non redundant peaks MAX

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SEQUENCES MAX

Download FASTA file

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Datasets Table for MAX

Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks
MAX			endothelial	umbilical-vein	ENCODE	Homo sapiens	ENCSR000EEZ	25,524
MAX			GM12878		ENCODE	Homo sapiens	ENCSR000DZF	3,694
MAX			Ishikawa		ENCODE	Homo sapiens	ENCSR000BTY	53,272
MAX			liver		ENCODE	Homo sapiens	ENCSR521IID	34,559
MAX			liver		ENCODE	Homo sapiens	ENCSR847DIT	43,893
MAX			NB4		ENCODE	Homo sapiens	ENCSR000EHS	13,556
MAX			A-549		ENCODE	Homo sapiens	ENCSR000BTJ	46,199
MAX			A-549		ENCODE	Homo sapiens	ENCSR000DYG	15,602
MAX			Hep-G2		ENCODE	Homo sapiens	ENCSR000BTM	58,767
MAX			Hep-G2		ENCODE	Homo sapiens	ENCSR000EDS	32,215
MAX			K-562		ENCODE	Homo sapiens	ENCSR000BLP	123,763
MAX			K-562		ENCODE	Homo sapiens	ENCSR000EFV	75,998
MAX			K-562		ENCODE	Homo sapiens	ENCSR000FAE	9,793
MAX			MCF-7		ENCODE	Homo sapiens	ENCSR000BUL	67,050
MAX			SK-N-SH		ENCODE	Homo sapiens	ENCSR000BVD	62,829
MAX			WA01		ENCODE	Homo sapiens	ENCSR000BSJ	108,406
MAX			WA01		ENCODE	Homo sapiens	ENCSR000EUP	24,844
MAX			HCT-116		ENCODE	Homo sapiens	ENCSR000BSH	25,649
MAX			HeLa-S3		ENCODE	Homo sapiens	ENCSR000ECN	45,371
MAX			HeLa-S3		ENCODE	Homo sapiens	ENCSR000EZF	56,449
MAX			H128		GEO	Homo sapiens	GSE41105	26,463
MAX			MDA-MB-468		GEO	Homo sapiens	GSE81381	31,789
MAX			MKL-1		GEO	Homo sapiens	GSE69877	110,398
MAX			NCI-H2171		GEO	Homo sapiens	GSE36354	79,100
MAX			NCI-H2171		GEO	Homo sapiens	GSE41105	80,226
MAX			P493-6		GEO	Homo sapiens	GSE36354	49,269
MAX			P493-6	CMYC_1H	GEO	Homo sapiens	GSE36354	38,471
MAX			P493-6	CMYC_24H	GEO	Homo sapiens	GSE36354	18,841
MAX			P493-6		GEO	Homo sapiens	GSE42262	27,954
MAX			U-87MG		GEO	Homo sapiens	GSE36354	98,698
MAX			MM1-S	JQ1	GEO	Homo sapiens	GSE42161	298
Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks