LEF1
Information LEF1
- Description
This gene encodes a transcription factor belonging to a family of proteins that share homology with the high mobility group protein-1. The protein encoded by this gene can bind to a functionally important site in the T-cell receptor-alpha enhancer, thereby conferring maximal enhancer activity. This transcription factor is involved in the Wnt signaling pathway, and it may function in hair cell differentiation and follicle morphogenesis. Mutations in this gene have been found in somatic sebaceous tumors. This gene has also been linked to other cancers, including androgen-independent prostate cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]
- Full Name
lymphoid enhancer binding factor 1
- Source NCBI
ReMap Statistics
- Datasets
- 5
- Biotypes
- 3
- Peaks
- 23,617
- Non-redundant peaks
- 22,363
TF Classification
- Super Class
- Other all-alpha-helical DNA-binding domains
- Class
- High-mobility group (HMG) domain factors
- Familly
- TCF-7-related factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- MA0768
- Ensembl
- ENSG00000138795
- UniProt
- Q9UJU2
- Genevisible
- Q9UJU2
- RefSeq
- NM_001130713
- Aliases
- TCF10; TCF1ALPHA; TCF7L3
Datasets Table for LEF1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| LEF1 | HEK293T | ENCODE | Homo sapiens | ENCSR240XWM | 288 | |||
| LEF1 | K-562 | ENCODE | Homo sapiens | ENCSR343ELW | 20,867 | |||
| LEF1 | K-562 | ENCODE | Homo sapiens | ENCSR832OGB | 1,010 | |||
| LEF1 | hESC | GEO | Homo sapiens | GSE64758 | 442 | |||
| LEF1 | hESC | WNT3A | GEO | Homo sapiens | GSE64758 | 1,010 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |