KMT2B
Information KMT2B
- Description
This gene encodes a protein which contains multiple domains including a CXXC zinc finger, three PHD zinc fingers, two FY-rich domains, and a SET (suppressor of variegation, enhancer of zeste, and trithorax) domain. The SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. This gene is ubiquitously expressed in adult tissues. It is also amplified in solid tumor cell lines, and may be involved in human cancer. Two alternatively spliced transcript variants encoding distinct isoforms have been reported for this gene, however, the full length nature of the shorter transcript is not known. [provided by RefSeq, Jul 2008]
- Full Name
lysine methyltransferase 2B
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 89,700
- Non-redundant peaks
- 60,336
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- CXXC zinc finger factors
- Familly
- CpG-binding proteins
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000272333
- UniProt
- Q9UMN6
- Genevisible
- Q9UMN6
- RefSeq
- NM_014727
- Aliases
- CXXC10; DYT28; HRX2; KIAA0304; MLL1B; MLL2; MLL4; TRX2; WBP-7; WBP7
Datasets Table for KMT2B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| KMT2B | AML | GEO | Homo sapiens | GSE112074 | 32,673 | |||
| KMT2B | AML | OG86 | GEO | Homo sapiens | GSE112074 | 53,937 | ||
| KMT2B | B-cell | GERMINAL_CENTER_TONSIL | GEO | Homo sapiens | GSE67494 | 3,090 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |