CBFA2T2
Information CBFA2T2
- Description
In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008]
- Full Name
CBFA2/RUNX1 partner transcriptional co-repressor 2
- Source NCBI
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 65,375
- Non-redundant peaks
- 64,079
TF Classification
- Super Class
- Unknown
- Class
- Unknown
- Familly
- Unknown
- Sub Familly
- Unknown
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000078699
- UniProt
- O43439
- Genevisible
- O43439
- RefSeq
- NM_001032999
- Aliases
- EHT; MTGR1; ZMYND3; p85
Datasets Table for CBFA2T2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| CBFA2T2 | K-562 | ENCODE | Homo sapiens | ENCSR699PVC | 26,659 | |||
| CBFA2T2 | NCCIT | GEO | Homo sapiens | GSE71675 | 38,716 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |