BAP1
Information BAP1
- Description
This gene belongs to the ubiquitin C-terminal hydrolase subfamily of deubiquitinating enzymes that are involved in the removal of ubiquitin from proteins. The encoded enzyme binds to the breast cancer type 1 susceptibility protein (BRCA1) via the RING finger domain of the latter and acts as a tumor suppressor. In addition, the enzyme may be involved in regulation of transcription, regulation of cell cycle and growth, response to DNA damage and chromatin dynamics. Germline mutations in this gene may be associated with tumor predisposition syndrome (TPDS), which involves increased risk of cancers including malignant mesothelioma, uveal melanoma and cutaneous melanoma. [provided by RefSeq, May 2013]
- Full Name
BRCA1 associated protein 1
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 1
- Peaks
- 4,809
- Non-redundant peaks
- 4,487
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000163930
- UniProt
- Q92560
- Genevisible
- Q92560
- RefSeq
- NM_004656
- Aliases
- HUCEP-13; KIAA0272; UCHL2; hucep-6
Datasets Table for BAP1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| BAP1 | UM-RC-6 | GEO | Homo sapiens | GSE101987 | 1,702 | |||
| BAP1 | UM-RC-6 | BAP1-C91A-mutant | GEO | Homo sapiens | GSE101987 | 1,647 | ||
| BAP1 | UM-RC-6 | empty-vector | GEO | Homo sapiens | GSE101987 | 1,460 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |