ATRX

Information ATRX

Description

The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]

Full Name

ATRX chromatin remodeler

Source NCBI

ReMap Statistics

Datasets
3
Biotypes
3
Peaks
1,684
Non-redundant peaks
1,658

TF Classification

Super Class
Zinc-coordinating DNA-binding domains
Class
Other C4 zinc finger-type factors
Familly
GATA-type zinc fingers
Sub Familly
Single GATA-type zinc-finger

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000085224
UniProt
P46100
Genevisible
P46100
RefSeq
NM_000489
Aliases
JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
All peaks ATRX
Download BED file
Non redundant peaks ATRX
Download BED file
SEQUENCES ATRX
Download FASTA file
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Datasets Table for ATRX

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
ATRX erythroid GEO Homo sapiens GSE22162 1,283
ATRX LAN6 KOATRX GEO Homo sapiens GSE70920 208
ATRX K-562 KOATRX GEO Homo sapiens GSE70920 193
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.