ASCL1
Information ASCL1
- Description
This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein activates transcription by binding to the E box (5'-CANNTG-3'). Dimerization with other BHLH proteins is required for efficient DNA binding. This protein plays a role in the neuronal commitment and differentiation and in the generation of olfactory and autonomic neurons. Mutations in this gene may contribute to the congenital central hypoventilation syndrome (CCHS) phenotype in rare cases. [provided by RefSeq, Jul 2008]
- Full Name
achaete-scute family bHLH transcription factor 1
- Source NCBI
ReMap Statistics
- Datasets
- 8
- Biotypes
- 6
- Peaks
- 129,066
- Non-redundant peaks
- 73,171
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- MyoD / ASC-related factors
- Sub Familly
- Achaete-Scute-like factors
Source TFClass
External IDs
- JASPAR
- MA1100
- Ensembl
- ENSG00000139352
- UniProt
- P50553
- Genevisible
- P50553
- RefSeq
- NM_004316
- Aliases
- ASH1; HASH1; MASH1; bHLHa46
Datasets Table for ASCL1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ASCL1 | H128 | GEO | Homo sapiens | GSE69394 | 6,059 | |||
| ASCL1 | SCLC | ASCLM | GEO | Homo sapiens | GSE61197 | 203 | ||
| ASCL1 | SCLC | ASCLP | GEO | Homo sapiens | GSE61197 | 31,038 | ||
| ASCL1 | SCLC | ASCLP_NE | GEO | Homo sapiens | GSE61197 | 9,834 | ||
| ASCL1 | NCI-H2107 | GEO | Homo sapiens | GSE69394 | 22,341 | |||
| ASCL1 | NCI-H82 | GEO | Homo sapiens | GSE69394 | 26,105 | |||
| ASCL1 | NCI-H889 | GEO | Homo sapiens | GSE69394 | 31,933 | |||
| ASCL1 | G523NS | Dox | GEO | Homo sapiens | GSE87618 | 1,553 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |