ZIC2
Information ZIC2
- Description
This gene encodes a member of the ZIC family of C2H2-type zinc finger proteins. This protein functions as a transcriptional repressor and may regulate tissue specific expression of dopamine receptor D1. Expansion of an alanine repeat in the C-terminus of the encoded protein and other mutations in this gene cause holoprosencephaly type 5. Holoprosencephaly is the most common structural anomaly of the human brain. A polyhistidine tract polymorphism in this gene may be associated with increased risk of neural tube defects. This gene is closely linked to a gene encoding zinc finger protein of the cerebellum 5, a related family member on chromosome 13. [provided by RefSeq, Jul 2016]
- Full Name
Zic family member 2
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 89,521
- Non-redundant peaks
- 88,376
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000043355
- UniProt
- O95409
- Genevisible
- O95409
- RefSeq
- NM_007129
- Aliases
- HPE5
Datasets Table for ZIC2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ZIC2 | HEK293 | ENCODE | Homo sapiens | ENCSR728MWW | 87,817 | |||
| ZIC2 | BCBL-1 | latent | GEO | Homo sapiens | GSE102462 | 1,353 | ||
| ZIC2 | BCBL-1 | lytic | GEO | Homo sapiens | GSE102462 | 351 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |