TP63

Information TP63

Description

This gene encodes a member of the p53 family of transcription factors. The functional domains of p53 family proteins include an N-terminal transactivation domain, a central DNA-binding domain and an oligomerization domain. Alternative splicing of this gene and the use of alternative promoters results in multiple transcript variants encoding different isoforms that vary in their functional properties. These isoforms function during skin development and maintenance, adult stem/progenitor cell regulation, heart development and premature aging. Some isoforms have been found to protect the germline by eliminating oocytes or testicular germ cells that have suffered DNA damage. Mutations in this gene are associated with ectodermal dysplasia, and cleft lip/palate syndrome 3 (EEC3); split-hand/foot malformation 4 (SHFM4); ankyloblepharon-ectodermal defects-cleft lip/palate; ADULT syndrome (acro-dermato-ungual-lacrimal-tooth); limb-mammary syndrome; Rap-Hodgkin syndrome (RHS); and orofacial cleft 8. [provided by RefSeq, Aug 2016]

Full Name

tumor protein p63

Source NCBI

ReMap Statistics

Datasets
23
Biotypes
10
Peaks
492,748
Non-redundant peaks
162,190

TF Classification

Super Class
Immunoglobulin fold
Class
p53 domain factors
Familly
p53-related factors
Sub Familly
None

Source TFClass

External IDs

JASPAR
MA0525
Ensembl
ENSG00000073282
UniProt
Q9H3D4
Genevisible
Q9H3D4
RefSeq
NM_001114978
Aliases
AIS; B(p51A); B(p51B); EEC3; KET; LMS; NBP; OFC8; RHS; SHFM4; TP53CP; TP53L; TP73L; p40; p51; p53CP; p63; p73H; p73L
All peaks TP63
Download BED file
Non redundant peaks TP63
Download BED file
SEQUENCES TP63
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for TP63

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
TP63 TE-5 GEO Homo sapiens GSE106563 1,223
TP63 EP156T GEO Homo sapiens GSE43111 4,809
TP63 HaCaT caRAS_TGFB GEO Homo sapiens GSE60814 14,079
TP63 HaCaT dnRAS_TGFB GEO Homo sapiens GSE60814 8,126
TP63 HaCaT LacZ GEO Homo sapiens GSE60814 2,936
TP63 HaCaT LacZ_TGFB GEO Homo sapiens GSE60814 13,630
TP63 HCC95 GEO Homo sapiens GSE46837 3,158
TP63 keratinocyte GEO Homo sapiens GSE33571 41,268
TP63 keratinocyte diff GEO Homo sapiens GSE33571 67,437
TP63 keratinocyte GEO Homo sapiens GSE56674 30,106
TP63 keratinocyte ADRIA GEO Homo sapiens GSE56674 4,194
TP63 keratinocyte CISP GEO Homo sapiens GSE56674 27,804
TP63 keratinocyte D0 GEO Homo sapiens GSE59824 46,719
TP63 keratinocyte D2 GEO Homo sapiens GSE59824 53,232
TP63 keratinocyte D4 GEO Homo sapiens GSE59824 48,524
TP63 keratinocyte D7 GEO Homo sapiens GSE59824 44,355
TP63 keratinocyte epidermal GEO Homo sapiens GSE67382 26,801
TP63 keratinocyte epidermal_KDPAF GEO Homo sapiens GSE67382 14,350
TP63 KYSE70 GEO Homo sapiens GSE46837 2,868
TP63 TT GEO Homo sapiens GSE46837 6,456
TP63 JHU-029 GEO Homo sapiens GSE88859 15,134
TP63 MCF-10A DCIS GEO Homo sapiens GSE72009 15,364
TP63 MDA-MB-231 GEO Homo sapiens GSE72009 175
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.