TBX21
Information TBX21
- Description
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq, Jul 2008]
- Full Name
T-box transcription factor 21
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 144,588
- Non-redundant peaks
- 108,660
TF Classification
- Super Class
- Immunoglobulin fold
- Class
- T-Box factors
- Familly
- TBrain-related factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- MA0690
- Ensembl
- ENSG00000073861
- UniProt
- Q9UL17
- Genevisible
- Q9UL17
- RefSeq
- NM_013351
- Aliases
- T-PET; T-bet; TBET; TBLYM
Datasets Table for TBX21
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| TBX21 | GM12878 | ENCODE | Homo sapiens | ENCSR739IHN | 68,287 | |||
| TBX21 | CD4 | TH1 | GEO | Homo sapiens | GSE62482 | 21,384 | ||
| TBX21 | TH1 | CD3-CD28_donor2 | GEO | Homo sapiens | GSE81881 | 54,917 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |