STAT2
Information STAT2
- Description
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]
- Full Name
signal transducer and activator of transcription 2
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 7,840
- Non-redundant peaks
- 6,858
TF Classification
- Super Class
- Immunoglobulin fold
- Class
- STAT domain factors
- Familly
- STAT factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000170581
- UniProt
- P52630
- Genevisible
- P52630
- RefSeq
- NM_005419
- Aliases
- IMD44; ISGF-3; P113; STAT113
Datasets Table for STAT2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| STAT2 | K-562 | ENCODE | Homo sapiens | ENCSR000FAT | 2,556 | |||
| STAT2 | K-562 | ENCODE | Homo sapiens | ENCSR000FBC | 1,872 | |||
| STAT2 | GM12878 | GEO | Homo sapiens | GSE97661 | 3,412 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |