SSRP1
Information SSRP1
- Description
The protein encoded by this gene is a subunit of a heterodimer that, along with SUPT16H, forms chromatin transcriptional elongation factor FACT. FACT interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT and cisplatin-damaged DNA may be crucial to the anticancer mechanism of cisplatin. This encoded protein contains a high mobility group box which most likely constitutes the structure recognition element for cisplatin-modified DNA. This protein also functions as a co-activator of the transcriptional activator p63. An alternatively spliced transcript variant of this gene has been described, but its full-length nature is not known. [provided by RefSeq, Jul 2008]
- Full Name
structure specific recognition protein 1
- Source NCBI
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 41,097
- Non-redundant peaks
- 39,538
TF Classification
- Super Class
- Other all-alpha-helical DNA-binding domains
- Class
- High-mobility group (HMG) domain factors
- Familly
- WHSC1-related factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000149136
- UniProt
- Q08945
- Genevisible
- Q08945
- RefSeq
- NM_003146
- Aliases
- FACT; FACT80; T160
Datasets Table for SSRP1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SSRP1 | Hep-G2 | ENCODE | Homo sapiens | ENCSR571PDN | 23,595 | |||
| SSRP1 | HT-1080 | AclacinomycinA | GEO | Homo sapiens | GSE107595 | 5,997 | ||
| SSRP1 | HT-1080 | CBL0100 | GEO | Homo sapiens | GSE107595 | 5,673 | ||
| SSRP1 | hiF-T | GEO | Homo sapiens | GSE98758 | 5,832 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |