SRF
Information SRF
- Description
This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]
- Full Name
serum response factor
- Source NCBI
ReMap Statistics
- Datasets
- 10
- Biotypes
- 8
- Peaks
- 188,635
- Non-redundant peaks
- 130,778
TF Classification
- Super Class
- alpha-Helices exposed by beta-structures
- Class
- MADS box factors
- Familly
- Responders to external signals (SRF/RLM1)
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- MA0083
- Ensembl
- ENSG00000112658
- UniProt
- P11831
- Genevisible
- P11831
- RefSeq
- NM_001292001
- Aliases
- MCM1
Datasets Table for SRF
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SRF | GM12878 | ENCODE | Homo sapiens | ENCSR000BGE | 3,765 | |||
| SRF | GM12878 | ENCODE | Homo sapiens | ENCSR000BMI | 15,446 | |||
| SRF | GM12878 | ENCODE | Homo sapiens | ENCSR041XML | 14,594 | |||
| SRF | Ishikawa | ENCODE | Homo sapiens | ENCSR000BTD | 21,154 | |||
| SRF | Hep-G2 | ENCODE | Homo sapiens | ENCSR000BLV | 13,722 | |||
| SRF | K-562 | ENCODE | Homo sapiens | ENCSR000BLK | 10,302 | |||
| SRF | MCF-7 | ENCODE | Homo sapiens | ENCSR000BVA | 10,242 | |||
| SRF | WA01 | ENCODE | Homo sapiens | ENCSR000BIV | 5,916 | |||
| SRF | HCT-116 | ENCODE | Homo sapiens | ENCSR000BSC | 7,372 | |||
| SRF | A-673-clone-Asp114 | GEO | Homo sapiens | GSE92738 | 86,122 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |