SPI1

Information SPI1

Description: This gene encodes an ETS-domain transcription factor that activates gene expression during myeloid and B-lymphoid cell development. The nuclear protein binds to a purine-rich sequence known as the PU-box found near the promoters of target genes, and regulates their expression in coordination with other transcription factors and cofactors. The protein can also regulate alternative splicing of target genes. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Full Name: Spi-1 proto-oncogene; Source NCBI

ReMap Statistics

Datasets: 47
Biotypes: 21
Peaks: 3,859,757
Non-redundant peaks: 554,639

TF Classification

Super Class: Helix-turn-helix domains
Class: Tryptophan cluster factors
Familly: Ets-related factors
Sub Familly: Spi-like factors; Source TFClass

External IDs

JASPAR: MA0080
Ensembl: ENSG00000066336
UniProt: P17947
Genevisible: P17947
RefSeq: NM_001080547
Aliases: OF; PU.1; SFPI1; SPI-1; SPI-A

External links

All peaks SPI1

Download BED file

Non redundant peaks SPI1

Download BED file

SEQUENCES SPI1

Download FASTA file

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Datasets Table for SPI1

Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks
SPI1			GM12878		ENCODE	Homo sapiens	ENCSR000BGQ	80,881
SPI1			GM12891		ENCODE	Homo sapiens	ENCSR000BIJ	55,727
SPI1			LCL		ENA	Homo sapiens	ERP004110	183,775
SPI1			HL-60		ENCODE	Homo sapiens	ENCSR000BUW	92,220
SPI1			K-562		ENCODE	Homo sapiens	ENCSR000BGW	59,259
SPI1			THP-1	eGFP-Pam3csk-0h	GEO	Homo sapiens	GSE103477	107,254
SPI1			THP-1	eGFP-Pam3csk-4h	GEO	Homo sapiens	GSE103477	110,932
SPI1			THP-1	NS1-Pam3csk-0h	GEO	Homo sapiens	GSE103477	93,734
SPI1			THP-1	NS1-Pam3csk-4h	GEO	Homo sapiens	GSE103477	89,857
SPI1			U-937		ENA	Homo sapiens	ERP008568	104,872
SPI1			MDM	dNS1	GEO	Homo sapiens	GSE103477	141,944
SPI1			MDM	H5N1	GEO	Homo sapiens	GSE103477	143,742
SPI1			MDM	IFNb	GEO	Homo sapiens	GSE103477	121,793
SPI1			MDM	Mock	GEO	Homo sapiens	GSE103477	124,379
SPI1			CD34	ADULT	GEO	Homo sapiens	GSE70660	173,233
SPI1			CD34	FETAL	GEO	Homo sapiens	GSE70660	65,021
SPI1			dendrite		GEO	Homo sapiens	GSE58864	14,655
SPI1			DOHH2		GEO	Homo sapiens	GSE69558	83,343
SPI1			macrophage	IFNG	GEO	Homo sapiens	GSE47188	12,221
SPI1			macrophage	IL4	GEO	Homo sapiens	GSE47188	4,934
SPI1			macrophage	IFNG	GEO	Homo sapiens	GSE66594	170,070
SPI1			macrophage	IL4	GEO	Homo sapiens	GSE66594	188,903
SPI1			macrophage	TPP	GEO	Homo sapiens	GSE66594	125,888
SPI1			monocyte		GEO	Homo sapiens	GSE31621	53,628
SPI1			monocyte	MACROPHAGE	GEO	Homo sapiens	GSE31621	43,671
SPI1			K-562		GEO	Homo sapiens	GSE70482	62,723
SPI1			K-562		GEO	Homo sapiens	GSE74999	2,161
SPI1			K-562	NABUT	GEO	Homo sapiens	GSE74999	40,350
SPI1			K-562	SAHA	GEO	Homo sapiens	GSE74999	10,865
SPI1			Kasumi-1	SICTR	GEO	Homo sapiens	GSE60130	54,806
SPI1			Kasumi-1	SIRUNX1ETO	GEO	Homo sapiens	GSE60130	51,842
SPI1			NCI-H929		GEO	Homo sapiens	GSE56857	30,333
SPI1			OCI-Ly10		GEO	Homo sapiens	GSE56857	7,214
SPI1			OCI-Ly3		GEO	Homo sapiens	GSE56857	3,596
SPI1			OCI-Ly3	SHCTR	GEO	Homo sapiens	GSE56857	3,030
SPI1			OCI-Ly3	SHSPIB	GEO	Homo sapiens	GSE56857	641
SPI1			OCI-Ly7		GEO	Homo sapiens	GSE69558	36,121
SPI1			THP-1	DIFF	GEO	Homo sapiens	GSE25426	27,256
SPI1			THP-1	1-25-OH-2D3	GEO	Homo sapiens	GSE89178	229,174
SPI1			THP-1	EtOH	GEO	Homo sapiens	GSE89178	212,938
SPI1			AML		GEO	Homo sapiens	GSE112074	131,555
SPI1			AML	OG86	GEO	Homo sapiens	GSE112074	122,651
SPI1			ME-1		GEO	Homo sapiens	GSE46044	16,909
SPI1			RS4-11		GEO	Homo sapiens	GSE71616	10,201
SPI1			RS4-11	DEX	GEO	Homo sapiens	GSE71616	17,789
SPI1			monocyte		GEO	Homo sapiens	GSE98367	140,946
SPI1			monocyte	INFg	GEO	Homo sapiens	GSE98367	200,720
Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks