SMC1A

Information SMC1A

Description

Proper cohesion of sister chromatids is a prerequisite for the correct segregation of chromosomes during cell division. The cohesin multiprotein complex is required for sister chromatid cohesion. This complex is composed partly of two structural maintenance of chromosomes (SMC) proteins, SMC3 and either SMC1B or the protein encoded by this gene. Most of the cohesin complexes dissociate from the chromosomes before mitosis, although those complexes at the kinetochore remain. Therefore, the encoded protein is thought to be an important part of functional kinetochores. In addition, this protein interacts with BRCA1 and is phosphorylated by ATM, indicating a potential role for this protein in DNA repair. This gene, which belongs to the SMC gene family, is located in an area of the X-chromosome that escapes X inactivation. Mutations in this gene result in Cornelia de Lange syndrome. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]

Full Name

structural maintenance of chromosomes 1A

Source NCBI

ReMap Statistics

Datasets
22
Biotypes
14
Peaks
738,943
Non-redundant peaks
296,357

TF Classification

Super Class
Unknown
Class
Unknown
Familly
Unknown
Sub Familly
Unknown

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000072501
UniProt
Q14683
Genevisible
Q14683
RefSeq
NM_001281463
Aliases
CDLS2; DXS423E; KIAA0178; SB1.8; SMC1; SMC1L1; SMC1alpha; SMCB
All peaks SMC1A
Download BED file
Non redundant peaks SMC1A
Download BED file
SEQUENCES SMC1A
Download FASTA file
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Datasets Table for SMC1A

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
SMC1A GM12878 GEO Homo sapiens GSE93080 84,565
SMC1A LCL GEO Homo sapiens GSE38395 18,547
SMC1A BCBL-1 GEO Homo sapiens GSE38411 101,124
SMC1A A-549 GEO Homo sapiens GSE76893 62,895
SMC1A Hep-G2 GEO Homo sapiens GSE76893 65,889
SMC1A MCF-7 GEO Homo sapiens GSE76893 43,086
SMC1A HCT-116 GEO Homo sapiens GSE112000 13,752
SMC1A primary-epidermal-keratinocyte diff_d0 GEO Homo sapiens GSE84657 34,702
SMC1A primary-epidermal-keratinocyte diff_d3 GEO Homo sapiens GSE84657 43,349
SMC1A primary-epidermal-keratinocyte diff_d6 GEO Homo sapiens GSE84657 46,339
SMC1A Primary-epidermal-keratinocyte GEO Homo sapiens GSE85526 54,423
SMC1A monocyte GEO Homo sapiens GSE98367 98,345
SMC1A monocyte INFg GEO Homo sapiens GSE98367 71,927
SMC1A HAP1 GEO Homo sapiens GSE94992 18,395
SMC1A HAP1 SCC4KO GEO Homo sapiens GSE94992 5,853
SMC1A HAP1 WaplKO-33 GEO Homo sapiens GSE94992 39,289
SMC1A HAP1 WaplKO-33_SCC4KO GEO Homo sapiens GSE94992 28,258
SMC1A HMEC-1 GEO Homo sapiens GSE101921 24,948
SMC1A MCF-10A GEO Homo sapiens GSE101921 26,185
SMC1A HCAEC GEO Homo sapiens GSE101921 75,631
SMC1A HCT-116 RAD21-mAC GEO Homo sapiens GSE104888 41,374
SMC1A HCT-116 RAD21-mAC_500uM_auxin GEO Homo sapiens GSE104888 7,079
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

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Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.