SMAD3
Information SMAD3
- Description
The protein encoded by this gene belongs to the SMAD, a family of proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. SMAD proteins are signal transducers and transcriptional modulators that mediate multiple signaling pathways. This protein functions as a transcriptional modulator activated by transforming growth factor-beta and is thought to play a role in the regulation of carcinogenesis. [provided by RefSeq, Apr 2009]
- Full Name
SMAD family member 3
- Source NCBI
ReMap Statistics
- Datasets
- 25
- Biotypes
- 9
- Peaks
- 588,496
- Non-redundant peaks
- 241,533
TF Classification
- Super Class
- beta-Hairpin exposed by an alpha/beta-scaffold
- Class
- SMAD/NF-1 DNA-binding domain factors
- Familly
- SMAD factors
- Sub Familly
- Regulatory Smads (R-Smad)
Source TFClass
External IDs
- JASPAR
- MA0795
- Ensembl
- ENSG00000166949
- UniProt
- P84022
- Genevisible
- P84022
- RefSeq
- NM_001145102
- Aliases
- HSPC193; HsT17436; JV15-2; LDS1C; LDS3; MADH3
Datasets Table for SMAD3
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| SMAD3 | HCC1954 | GEO | Homo sapiens | GSE104760 | 61,772 | |||
| SMAD3 | HCC1954 | TGFb | GEO | Homo sapiens | GSE104760 | 65,263 | ||
| SMAD3 | MDA-MB-231 | GEO | Homo sapiens | GSE104760 | 106,365 | |||
| SMAD3 | MDA-MB-231 | TGFb | GEO | Homo sapiens | GSE104760 | 110,217 | ||
| SMAD3 | HMLE | GEO | Homo sapiens | GSE104760 | 879 | |||
| SMAD3 | HMLE | Doxycicline_TGFb | GEO | Homo sapiens | GSE104760 | 14,940 | ||
| SMAD3 | HMLE | TGFb | GEO | Homo sapiens | GSE104760 | 4,633 | ||
| SMAD3 | BGO3 | GEO | Homo sapiens | GSE21614 | 17,097 | |||
| SMAD3 | BGO3 | GEO | Homo sapiens | GSE36578 | 34,287 | |||
| SMAD3 | BGO3 | DIFF_0H | GEO | Homo sapiens | GSE36578 | 2,615 | ||
| SMAD3 | BGO3 | DIFF_2H | GEO | Homo sapiens | GSE36578 | 8,877 | ||
| SMAD3 | BGO3 | DIFF_48H | GEO | Homo sapiens | GSE36578 | 8,318 | ||
| SMAD3 | endoderm | GEO | Homo sapiens | GSE29422 | 4,526 | |||
| SMAD3 | hESC | GEO | Homo sapiens | GSE29422 | 7,031 | |||
| SMAD3 | hESC | GEO | Homo sapiens | GSE75297 | 160 | |||
| SMAD3 | hESC | DIFF_D0 | GEO | Homo sapiens | GSE75297 | 89 | ||
| SMAD3 | hESC | DIFF_D1 | GEO | Homo sapiens | GSE75297 | 277 | ||
| SMAD3 | hESC | DIFF_D2 | GEO | Homo sapiens | GSE75297 | 103 | ||
| SMAD3 | LX2 | CALCIPOTRIOL_TGFB1 | GEO | Homo sapiens | GSE38103 | 29,626 | ||
| SMAD3 | LX2 | TGFB1 | GEO | Homo sapiens | GSE38103 | 1,235 | ||
| SMAD3 | MDA-MB-231 | GEO | Homo sapiens | GSE92443 | 170 | |||
| SMAD3 | MDA-MB-231 | TGF-beta | GEO | Homo sapiens | GSE92443 | 5,119 | ||
| SMAD3 | HCASMC | GEO | Homo sapiens | GSE115317 | 188 | |||
| SMAD3 | NCI-H441 | GEO | Homo sapiens | GSE51509 | 49,883 | |||
| SMAD3 | NCI-H441 | SIITTF1 | GEO | Homo sapiens | GSE51509 | 54,826 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |