RUNX1T1
Information RUNX1T1
- Description
This gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]
- Full Name
RUNX1 partner transcriptional co-repressor 1
- Source NCBI
ReMap Statistics
- Datasets
- 7
- Biotypes
- 2
- Peaks
- 215,376
- Non-redundant peaks
- 102,937
TF Classification
- Super Class
- Unknown
- Class
- Unknown
- Familly
- Unknown
- Sub Familly
- Unknown
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000079102
- UniProt
- Q06455
- Genevisible
- Q06455
- RefSeq
- NM_001198625
- Aliases
- AML1-MTG8; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2
Datasets Table for RUNX1T1
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| RUNX1T1 | Kasumi-1 | GEO | Homo sapiens | GSE102697 | 46,025 | |||
| RUNX1T1 | Kasumi-1 | CEBPA-ER | GEO | Homo sapiens | GSE102697 | 27,679 | ||
| RUNX1T1 | Kasumi-1 | CEBPA-ER_E2 | GEO | Homo sapiens | GSE102697 | 32,864 | ||
| RUNX1T1 | Kasumi-1 | E2 | GEO | Homo sapiens | GSE102697 | 26,813 | ||
| RUNX1T1 | CD34 | GEO | Homo sapiens | GSE80773 | 34,410 | |||
| RUNX1T1 | Kasumi-1 | GEO | Homo sapiens | GSE43834 | 28,880 | |||
| RUNX1T1 | Kasumi-1 | GEO | Homo sapiens | GSE65427 | 18,705 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |