REST

Information REST

Description: This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]
Full Name: RE1 silencing transcription factor; Source NCBI

ReMap Statistics

Datasets: 35
Biotypes: 21
Peaks: 710,632
Non-redundant peaks: 299,483

TF Classification

Super Class: Zinc-coordinating DNA-binding domains
Class: C2H2 zinc finger factors
Familly: Factors with multiple dispersed zinc fingers
Sub Familly: unclassified; Source TFClass

External IDs

JASPAR: MA0138
Ensembl: ENSG00000084093
UniProt: Q13127
Genevisible: Q13127
RefSeq: NM_001193508
Aliases: DFNA27; GINGF5; HGF5; NRSF; WT6; XBR

External links

All peaks REST

Download BED file

Non redundant peaks REST

Download BED file

SEQUENCES REST

Download FASTA file

DOWNLOAD All ReMap

Got to catalogue

Datasets Table for REST

Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks
REST			GM12878		ENCODE	Homo sapiens	ENCSR000BGF	8,691
REST			GM12878		ENCODE	Homo sapiens	ENCSR000BQS	20,703
REST			HEK293		ENCODE	Homo sapiens	ENCSR896UBV	27,224
REST			hepatocyte		ENA	Homo sapiens	ERP000395	1,186
REST			Ishikawa		ENCODE	Homo sapiens	ENCSR000BUU	13,561
REST			liver		ENCODE	Homo sapiens	ENCSR867WPH	41,981
REST			liver		ENCODE	Homo sapiens	ENCSR893QWP	27,993
REST			neural		ENCODE	Homo sapiens	ENCSR000BTV	57,836
REST			PFSK1		ENCODE	Homo sapiens	ENCSR000BJP	7,954
REST			PFSK1		ENCODE	Homo sapiens	ENCSR000BOX	20,958
REST			A-549		ENCODE	Homo sapiens	ENCSR000BQP	49,377
REST			A-549		ENCODE	Homo sapiens	ENCSR892DRK	12,543
REST			GM23338		ENCODE	Homo sapiens	ENCSR871KYB	8,114
REST			Hep-G2		ENCODE	Homo sapiens	ENCSR000BJL	5,384
REST			Hep-G2		ENCODE	Homo sapiens	ENCSR000BOT	27,622
REST			HL-60		ENCODE	Homo sapiens	ENCSR000BTF	11,250
REST			K-562		ENCODE	Homo sapiens	ENCSR000ATM	7,923
REST			K-562		ENCODE	Homo sapiens	ENCSR000BMW	54,019
REST			K-562		ENCODE	Homo sapiens	ENCSR137ZMQ	53,595
REST			MCF-7		ENCODE	Homo sapiens	ENCSR000BSP	14,982
REST			PANC-1		ENCODE	Homo sapiens	ENCSR000BJO	29,831
REST			PANC-1		ENCODE	Homo sapiens	ENCSR000BPK	19,227
REST			PANC-1		ENCODE	Homo sapiens	ENCSR000BUP	5,012
REST			SK-N-SH		ENCODE	Homo sapiens	ENCSR000BJJ	7,774
REST			SK-N-SH		ENCODE	Homo sapiens	ENCSR000BOZ	82,825
REST			WA01		ENCODE	Homo sapiens	ENCSR000BHM	25,812
REST			WA01		ENCODE	Homo sapiens	ENCSR663WAR	4,852
REST			HeLa-S3		ENCODE	Homo sapiens	ENCSR000BMN	23,160
REST			HCT-116		ENCODE	Homo sapiens	ENCSR000BVI	4,429
REST			CD4		GEO	Homo sapiens	GSE49570	15,960
REST			GP5D		GEO	Homo sapiens	GSE51234	3,098
REST			GP5D	SIRAD21	GEO	Homo sapiens	GSE51234	2,793
REST			K-562		GEO	Homo sapiens	GSE70482	8,834
REST			NCI-H295R		GEO	Homo sapiens	GSE49014	2,108
REST			NCI-H295R	SF1	GEO	Homo sapiens	GSE49014	2,021
Target name	Target modification	Ecotype/Strain	Biotype	Biotype modification	Source	Species	Experiment	Peaks