PHOX2B
Information PHOX2B
- Description
The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins localized to the nucleus. The protein functions as a transcription factor involved in the development of several major noradrenergic neuron populations and the determination of neurotransmitter phenotype. The gene product is linked to enhancement of second messenger-mediated activation of the dopamine beta-hydroylase, c-fos promoters and several enhancers, including cyclic amp-response element and serum-response element. Expansion of a 20 amino acid polyalanine tract in this protein by 5-13 aa has been associated with congenital central hypoventilation syndrome. [provided by RefSeq, Jul 2016]
- Full Name
paired like homeobox 2B
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 307,288
- Non-redundant peaks
- 204,466
TF Classification
- Super Class
- NA
- Class
- NA
- Familly
- NA
- Sub Familly
- NA
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000109132
- UniProt
- Q99453
- Genevisible
- Q99453
- RefSeq
- NM_003924
- Aliases
- CCHS; NBLST2; NBPhox; PMX2B; Phox2b
Datasets Table for PHOX2B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| PHOX2B | CLB-Ga | GEO | Homo sapiens | GSE90683 | 71,490 | |||
| PHOX2B | Kelly | GEO | Homo sapiens | GSE94822 | 163,879 | |||
| PHOX2B | SK-N-BE2-C | GEO | Homo sapiens | GSE94822 | 71,919 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |