PDX1

Information PDX1

Description

The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturity onset diabetes of the young type 4 (MODY4). [provided by RefSeq, Aug 2017]

Full Name

pancreatic and duodenal homeobox 1

Source NCBI

ReMap Statistics

Datasets
5
Biotypes
4
Peaks
197,716
Non-redundant peaks
138,559

TF Classification

Super Class
Helix-turn-helix domains
Class
Homeo domain factors
Familly
HOX-related factors
Sub Familly
PDX

Source TFClass

External IDs

JASPAR
MA0132
Ensembl
ENSG00000139515
UniProt
P52945
Genevisible
P52945
RefSeq
NM_000209
Aliases
GSF; IDX-1; IPF1; IUF1; MODY4; PAGEN1; PDX-1; STF-1
All peaks PDX1
Download BED file
Non redundant peaks PDX1
Download BED file
SEQUENCES PDX1
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for PDX1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
PDX1 islet ENA Homo sapiens ERP001456 54,902
PDX1 islet ENA Homo sapiens ERP004003 80,819
PDX1 H9 ENA Homo sapiens ERP004206 2,634
PDX1 hiPSC derived_PPs GEO Homo sapiens GSE106949 47,573
PDX1 hESC GEO Homo sapiens GSE58685 11,788
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.