NMYC

Information NMYC

Description

This gene is a member of the MYC family and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the nucleus and must dimerize with another bHLH protein in order to bind DNA. Amplification of this gene is associated with a variety of tumors, most notably neuroblastomas. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2014]

Full Name

MYCN proto-oncogene, bHLH transcription factor

Source NCBI

ReMap Statistics

Datasets
26
Biotypes
13
Peaks
13,414
Non-redundant peaks
9,868

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
bHLH-ZIP factors
Sub Familly
Myc / Max factors

Source TFClass

External IDs

JASPAR
MA0104
Ensembl
ENSG00000134323
UniProt
P04198
Genevisible
P04198
RefSeq
NM_001293228
Aliases
MODED; MYCNOT; N-myc; NMYC; ODED; bHLHe37
All peaks NMYC
Download BED file
Non redundant peaks NMYC
Download BED file
SEQUENCES NMYC
Download FASTA file
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Datasets Table for NMYC

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MYCN SH-SY5Y ENA Homo sapiens ERP013415 399
MYCN SH-SY5Y OVERMYCN_24H ENA Homo sapiens ERP013415 132
MYCN SH-SY5Y OVERMYCN_48H ENA Homo sapiens ERP013415 86
MYCN SMS-KCN ENA Homo sapiens ERP013415 145
MYCN SMS-KCNR ENA Homo sapiens ERP013415 117
MYCN BE2C GEO Homo sapiens GSE72640 658
MYCN BE2C GEO Homo sapiens GSE80151 41,892
MYCN Kelly GEO Homo sapiens GSE80151 8,013
MYCN NGP GEO Homo sapiens GSE80151 17,875
MYCN RH4 GEO Homo sapiens GSE83726 27,092
MYCN SH-EP 2h GEO Homo sapiens GSE80151 866
MYCN SH-EP 6h GEO Homo sapiens GSE80151 1,862
MYCN SHEP-21N GEO Homo sapiens GSE80151 64,226
MYCN SHEP-21N 24h GEO Homo sapiens GSE80151 21,263
MYCN SHEP-21N DOX_0H GEO Homo sapiens GSE80151 22,668
MYCN SHEP-21N DOX_24H GEO Homo sapiens GSE80151 18,430
MYCN SK-N-BE2-C GEO Homo sapiens GSE80151 41,377
MYCN MYCN-3 high GEO Homo sapiens GSE83317 1,026
MYCN MYCN-3 low GEO Homo sapiens GSE83317 20,175
MYCN Kelly GEO Homo sapiens GSE94782 41,832
MYCN Kelly GEO Homo sapiens GSE94822 65,700
MYCN NGP GEO Homo sapiens GSE94782 322,633
MYCN NB-1643 GEO Homo sapiens GSE94782 17,160
MYCN SK-N-BE2-C GEO Homo sapiens GSE94822 34,528
MYCN IMR-5 CD532 GEO Homo sapiens GSE78957 6,846
MYCN IMR-5 DMSO GEO Homo sapiens GSE78957 6,568
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

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The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.