NFYA
Information NFYA
- Description
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit A associates with a tight dimer composed of the B and C subunits, resulting in a trimer that binds to DNA with high specificity and affinity. The sequence specific interactions of the complex are made by the A subunit, suggesting a role as the regulatory subunit. In addition, there is evidence of post-transcriptional regulation in this gene product, either by protein degradation or control of translation. Further regulation is represented by alternative splicing in the glutamine-rich activation domain, with clear tissue-specific preferences for the two isoforms. [provided by RefSeq, Jul 2008]
- Full Name
nuclear transcription factor Y subunit alpha
- Source NCBI
ReMap Statistics
- Datasets
- 4
- Biotypes
- 3
- Peaks
- 39,929
- Non-redundant peaks
- 29,289
TF Classification
- Super Class
- Other all-alpha-helical DNA-binding domains
- Class
- Heteromeric CCAAT-binding factors
- Familly
- Heteromeric CCAAT-binding factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- MA0060
- Ensembl
- ENSG00000001167
- UniProt
- P23511
- Genevisible
- P23511
- RefSeq
- NM_002505
- Aliases
- CBF-A; CBF-B; HAP2; NF-YA
Datasets Table for NFYA
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| NFYA | GM12878 | ENCODE | Homo sapiens | ENCSR000DNN | 1,023 | |||
| NFYA | K-562 | ENCODE | Homo sapiens | ENCSR000EGR | 4,798 | |||
| NFYA | HeLa-S3 | ENCODE | Homo sapiens | ENCSR000DNS | 7,772 | |||
| NFYA | K-562 | GEO | Homo sapiens | GSE26439 | 26,336 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |