NFKB2

Information NFKB2

Description

This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Full Name

nuclear factor kappa B subunit 2

Source NCBI

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
25,374
Non-redundant peaks
25,374

TF Classification

Super Class
Immunoglobulin fold
Class
Rel homology region (RHR) factors
Familly
NF-kappaB-related factors
Sub Familly
NF-kappaB p50 subunit-like factors

Source TFClass

External IDs

JASPAR
MA0778
Ensembl
ENSG00000077150
UniProt
Q00653
Genevisible
Q00653
RefSeq
NM_001077494
Aliases
CVID10; H2TF1; LYT-10; LYT10; NF-kB2; p100; p49/p100; p52
All peaks NFKB2
Download BED file
Non redundant peaks NFKB2
Download BED file
SEQUENCES NFKB2
Download FASTA file
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Datasets Table for NFKB2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NFKB2 L1236 GEO Homo sapiens GSE63736 25,374
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.