NFATC1

Information NFATC1

Description

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Full Name

nuclear factor of activated T cells 1

Source NCBI

ReMap Statistics

Datasets
3
Biotypes
2
Peaks
65,379
Non-redundant peaks
54,046

TF Classification

Super Class
Immunoglobulin fold
Class
Rel homology region (RHR) factors
Familly
NFAT-related factors
Sub Familly
None

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000131196
UniProt
O95644
Genevisible
O95644
RefSeq
NM_001278669
Aliases
NF-ATC; NF-ATc1.2; NFAT2; NFATc
All peaks NFATC1
Download BED file
Non redundant peaks NFATC1
Download BED file
SEQUENCES NFATC1
Download FASTA file
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Datasets Table for NFATC1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
NFATC1 GM12878 ENCODE Homo sapiens ENCSR000BQL 34,739
NFATC1 HUVEC-C GEO Homo sapiens GSE49428 14,520
NFATC1 HUVEC-C VEGF GEO Homo sapiens GSE49428 16,120
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.