MNT
Information MNT
- Description
The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]
- Full Name
MAX network transcriptional repressor
- Source NCBI
ReMap Statistics
- Datasets
- 6
- Biotypes
- 3
- Peaks
- 161,100
- Non-redundant peaks
- 90,747
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- bHLH-ZIP factors
- Sub Familly
- Mad-like factors
Source TFClass
External IDs
- JASPAR
- MA0825
- Ensembl
- ENSG00000070444
- UniProt
- Q99583
- Genevisible
- Q99583
- RefSeq
- NM_020310
- Aliases
- MAD6; MXD6; ROX; bHLHd3
Datasets Table for MNT
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| MNT | Hep-G2 | ENCODE | Homo sapiens | ENCSR261EDU | 38,181 | |||
| MNT | Hep-G2 | ENCODE | Homo sapiens | ENCSR730TBC | 16,711 | |||
| MNT | K-562 | ENCODE | Homo sapiens | ENCSR390VGH | 28,004 | |||
| MNT | K-562 | ENCODE | Homo sapiens | ENCSR512NLO | 29,687 | |||
| MNT | K-562 | ENCODE | Homo sapiens | ENCSR979QYJ | 14,170 | |||
| MNT | MCF-7 | ENCODE | Homo sapiens | ENCSR663ZZZ | 34,347 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |