MED12

Information MED12

Description

The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. [provided by RefSeq, Aug 2009]

Full Name

mediator complex subunit 12

Source NCBI

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
1,473
Non-redundant peaks
1,473

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000184634
UniProt
Q93074
Genevisible
Q93074
RefSeq
NM_005120
Aliases
ARC240; CAGH45; FGS1; HOPA; KIAA0192; MED12S; OHDOX; OKS; OPA1; TNRC11; TRAP230
All peaks MED12
Download BED file
Non redundant peaks MED12
Download BED file
SEQUENCES MED12
Download FASTA file
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Datasets Table for MED12

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MED12 MCF-7 siCTL_E2 GEO Homo sapiens GSE101559 1,473
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

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The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.