MBD2

Information MBD2

Description

DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]

Full Name

methyl-CpG binding domain protein 2

Source NCBI

ReMap Statistics

Datasets
6
Biotypes
5
Peaks
49,742
Non-redundant peaks
41,860

TF Classification

Super Class
Unknown
Class
Unknown
Familly
Unknown
Sub Familly
Unknown

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000134046
UniProt
Q9UBB5
Genevisible
Q9UBB5
RefSeq
NM_003927
Aliases
DMTase; NY-CO-41
All peaks MBD2
Download BED file
Non redundant peaks MBD2
Download BED file
SEQUENCES MBD2
Download FASTA file
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Datasets Table for MBD2

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
MBD2 K-562 ENCODE Homo sapiens ENCSR221GAN 18,485
MBD2 MCF-7 ENCODE Homo sapiens ENCSR940MHE 23,663
MBD2 HeLa GEO Homo sapiens GSE41006 5,943
MBD2 HMLER GEO Homo sapiens GSE63233 441
MBD2 HMEC-1 GEO Homo sapiens GSE63233 969
MBD2 MCF-7 GEO Homo sapiens GSE54693 241
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.