IRF4
Information IRF4
- Description
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
- Full Name
interferon regulatory factor 4
- Source NCBI
ReMap Statistics
- Datasets
- 7
- Biotypes
- 5
- Peaks
- 201,994
- Non-redundant peaks
- 146,846
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Tryptophan cluster factors
- Familly
- Interferon-regulatory factors
- Sub Familly
- None
Source TFClass
External IDs
- JASPAR
- MA1419
- Ensembl
- ENSG00000137265
- UniProt
- Q15306
- Genevisible
- Q15306
- RefSeq
- NM_001195286
- Aliases
- LSIRF; MUM1; NF-EM5; SHEP8
Datasets Table for IRF4
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| IRF4 | GM12878 | ENCODE | Homo sapiens | ENCSR000BGY | 57,248 | |||
| IRF4 | NCI-H929 | GEO | Homo sapiens | GSE56857 | 40,496 | |||
| IRF4 | OCI-Ly3 | GEO | Homo sapiens | GSE56857 | 9,085 | |||
| IRF4 | OCI-Ly3 | SHCTR | GEO | Homo sapiens | GSE56857 | 8,295 | ||
| IRF4 | OCI-Ly3 | SHSPIB | GEO | Homo sapiens | GSE56857 | 747 | ||
| IRF4 | MM1-S | GEO | Homo sapiens | GSE49224 | 81,051 | |||
| IRF4 | KK-1 | GEO | Homo sapiens | GSE94732 | 5,072 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |