HNF4A
Information HNF4A
- Description
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
- Full Name
hepatocyte nuclear factor 4 alpha
- Source NCBI
ReMap Statistics
- Datasets
- 15
- Biotypes
- 6
- Peaks
- 518,673
- Non-redundant peaks
- 207,390
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- Nuclear receptors with C4 zinc fingers
- Familly
- RXR-related receptors (NR2)
- Sub Familly
- HNF-4 (NR2A)
Source TFClass
External IDs
- JASPAR
- MA0114
- Ensembl
- ENSG00000101076
- UniProt
- P41235
- Genevisible
- P41235
- RefSeq
- NM_000457
- Aliases
- FRTS4; HNF4; HNF4a7; HNF4a8; HNF4a9; HNF4alpha; MODY; MODY1; NR2A1; NR2A21; TCF; TCF14
Datasets Table for HNF4A
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HNF4A | liver | ENCODE | Homo sapiens | ENCSR445QRF | 107,053 | |||
| HNF4A | liver | ENCODE | Homo sapiens | ENCSR601OGE | 94,118 | |||
| HNF4A | liver | ENA | Homo sapiens | ERP002306 | 64,642 | |||
| HNF4A | Hep-G2 | ENCODE | Homo sapiens | ENCSR000BLF | 62,632 | |||
| HNF4A | Hep-G2 | ENCODE | Homo sapiens | ENCSR000EEU | 21,163 | |||
| HNF4A | Hep-G2 | ENA | Homo sapiens | ERP000209 | 39,187 | |||
| HNF4A | CACO2 | DIFF | GEO | Homo sapiens | GSE23436 | 64,374 | ||
| HNF4A | CACO2 | PROLIF | GEO | Homo sapiens | GSE23436 | 19,748 | ||
| HNF4A | GP5D | GEO | Homo sapiens | GSE51234 | 14,885 | |||
| HNF4A | GP5D | SIRAD21 | GEO | Homo sapiens | GSE51234 | 4,148 | ||
| HNF4A | LoVo | PHASEM | GEO | Homo sapiens | GSE51290 | 1,507 | ||
| HNF4A | LoVo | PHASES | GEO | Homo sapiens | GSE51290 | 11,657 | ||
| HNF4A | HCT-116 | GEO | Homo sapiens | GSE62890 | 6,750 | |||
| HNF4A | HCT-116 | TCF4 | GEO | Homo sapiens | GSE62890 | 3,900 | ||
| HNF4A | HCT-116 | TCF4_DOX | GEO | Homo sapiens | GSE62890 | 2,909 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |