HNF1B
Information HNF1B
- Description
This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
- Full Name
HNF1 homeobox B
- Source NCBI
ReMap Statistics
- Datasets
- 2
- Biotypes
- 2
- Peaks
- 31,985
- Non-redundant peaks
- 30,324
TF Classification
- Super Class
- Helix-turn-helix domains
- Class
- Homeo domain factors
- Familly
- POU domain factors
- Sub Familly
- HNF1-like factors
Source TFClass
External IDs
- JASPAR
- MA0153
- Ensembl
- ENSG00000276194
- UniProt
- P35680
- Genevisible
- P35680
- RefSeq
- NM_000458
- Aliases
- FJHN; HNF-1-beta; HNF-1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; TCF-2; TCF2; VHNF1
Datasets Table for HNF1B
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| HNF1B | H9 | ENA | Homo sapiens | ERP004206 | 2,760 | |||
| HNF1B | PDAC | GEO | Homo sapiens | GSE64557 | 29,225 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |