EWSR1

Information EWSR1

Description

This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11;22)(q24;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009]

Full Name

EWS RNA binding protein 1

Source NCBI

ReMap Statistics

Datasets
2
Biotypes
2
Peaks
4,188
Non-redundant peaks
4,183

TF Classification

Super Class
Unknown
Class
Unknown
Familly
Unknown
Sub Familly
Unknown

Source TFClass

External IDs

JASPAR
MA0149
Ensembl
ENSG00000182944
UniProt
Q01844
Genevisible
Q01844
RefSeq
NM_001163285
Aliases
EWS; EWS-FLI1; bK984G1.4
All peaks EWSR1
Download BED file
Non redundant peaks EWSR1
Download BED file
SEQUENCES EWSR1
Download FASTA file
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Datasets Table for EWSR1

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
EWSR1 K-562 ENCODE Homo sapiens ENCSR142YYA 4,172
EWSR1 HEK293 GEO Homo sapiens GSE73492 16
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.