ESR2
Information ESR2
- Description
This gene encodes a member of the family of estrogen receptors and superfamily of nuclear receptor transcription factors. The gene product contains an N-terminal DNA binding domain and C-terminal ligand binding domain and is localized to the nucleus, cytoplasm, and mitochondria. Upon binding to 17beta-estradiol or related ligands, the encoded protein forms homo- or hetero-dimers that interact with specific DNA sequences to activate transcription. Some isoforms dominantly inhibit the activity of other estrogen receptor family members. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been fully characterized. [provided by RefSeq, Jul 2008]
- Full Name
estrogen receptor 2
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 2
- Peaks
- 40,709
- Non-redundant peaks
- 31,726
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- Nuclear receptors with C4 zinc fingers
- Familly
- Steroid hormone receptors (NR3)
- Sub Familly
- ER-like receptors (NR3A&B)
Source TFClass
External IDs
- JASPAR
- MA0258
- Ensembl
- ENSG00000140009
- UniProt
- Q92731
- Genevisible
- Q92731
- RefSeq
- NM_001040275
- Aliases
- ER-BETA; ESR-BETA; ESRB; ESTRB; Erb; NR3A2; ODG8
Datasets Table for ESR2
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ESR2 | MDA-MB-231 | estradiol | GEO | Homo sapiens | GSE108979 | 30,205 | ||
| ESR2 | MDA-MB-231 | LY500307 | GEO | Homo sapiens | GSE108979 | 8,703 | ||
| ESR2 | MCF-7 | C412_E2 | GEO | Homo sapiens | GSE48096 | 1,801 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |