CLOCK

Information CLOCK

Description

The protein encoded by this gene plays a central role in the regulation of circadian rhythms. The protein encodes a transcription factor of the basic helix-loop-helix (bHLH) family and contains DNA binding histone acetyltransferase activity. The encoded protein forms a heterodimer with ARNTL (BMAL1) that binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Polymorphisms in this gene may be associated with behavioral changes in certain populations and with obesity and metabolic syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

Full Name

clock circadian regulator

Source NCBI

ReMap Statistics

Datasets
14
Biotypes
5
Peaks
92,413
Non-redundant peaks
81,973

TF Classification

Super Class
Basic domains
Class
Basic helix-loop-helix factors (bHLH)
Familly
PAS domain factors
Sub Familly
Arnt-like factors

Source TFClass

External IDs

JASPAR
MA0819
Ensembl
ENSG00000134852
UniProt
O15516
Genevisible
O15516
RefSeq
NM_001267843
Aliases
KAT13D; KIAA0334; bHLHe8
All peaks CLOCK
Download BED file
Non redundant peaks CLOCK
Download BED file
SEQUENCES CLOCK
Download FASTA file
DOWNLOAD All ReMap
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Datasets Table for CLOCK

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CLOCK MCF-7 ENCODE Homo sapiens ENCSR699YFX 10,884
CLOCK MCF-7 ENCODE Homo sapiens ENCSR934JDG 10,151
CLOCK U2OS GEO Homo sapiens GSE44236 24,360
CLOCK neural progenitor-O62409 GEO Homo sapiens GSE96659 408
CLOCK BA10-neocortex 0 GEO Homo sapiens GSE96659 667
CLOCK BA10-neocortex 1 GEO Homo sapiens GSE96659 1,837
CLOCK BA10-neocortex 2 GEO Homo sapiens GSE96659 11,458
CLOCK BA10-neocortex 3 GEO Homo sapiens GSE96659 1,107
CLOCK BA10-neocortex 4 GEO Homo sapiens GSE96659 2,027
CLOCK BA40-neocortex 0 GEO Homo sapiens GSE96659 11,399
CLOCK BA40-neocortex 1 GEO Homo sapiens GSE96659 981
CLOCK BA40-neocortex 2 GEO Homo sapiens GSE96659 1,076
CLOCK BA40-neocortex 3 GEO Homo sapiens GSE96659 14,295
CLOCK BA40-neocortex 4 GEO Homo sapiens GSE96659 1,763
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.