CIITA

Information CIITA

Description

This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the "master control factor" for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]

Full Name

class II major histocompatibility complex transactivator

Source NCBI

ReMap Statistics

Datasets
1
Biotypes
1
Peaks
1,552
Non-redundant peaks
1,552

TF Classification

Super Class
Unknown
Class
Unknown
Familly
Unknown
Sub Familly
Unknown

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000179583
UniProt
P33076
Genevisible
P33076
RefSeq
NM_000246
Aliases
C2TA; CIITAIV; MHC2TA; NLRA
All peaks CIITA
Download BED file
Non redundant peaks CIITA
Download BED file
SEQUENCES CIITA
Download FASTA file
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Datasets Table for CIITA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CIITA Raji AB1 GEO Homo sapiens GSE52941 1,552
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.