CD74

Information CD74

Description

The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]

Full Name

CD74 molecule

Source NCBI

ReMap Statistics

Datasets
4
Biotypes
1
Peaks
18,333
Non-redundant peaks
11,733

TF Classification

Super Class
NA
Class
NA
Familly
NA
Sub Familly
NA

Source TFClass

External IDs

JASPAR
Ensembl
ENSG00000019582
UniProt
P04233
Genevisible
P04233
RefSeq
NM_001025158
Aliases
DHLAG; HLADG; II; Ia-GAMMA; p33
All peaks CD74
Download BED file
Non redundant peaks CD74
Download BED file
SEQUENCES CD74
Download FASTA file
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Datasets Table for CD74

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
CD74 CLL p1 GEO Homo sapiens GSE88955 5,640
CD74 CLL p2 GEO Homo sapiens GSE88955 1,794
CD74 CLL p3 GEO Homo sapiens GSE88955 1,921
CD74 CLL p4 GEO Homo sapiens GSE88955 8,978
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

You are using the 2020 ReMap (3rd) release.
The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

Inserm TAGC
AMU AMU-MESO

This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.