BCL6
Information BCL6
- Description
The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of STAT-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- Full Name
BCL6 transcription repressor
- Source NCBI
ReMap Statistics
- Datasets
- 8
- Biotypes
- 5
- Peaks
- 298,846
- Non-redundant peaks
- 202,668
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- C2H2 zinc finger factors
- Familly
- More than 3 adjacent zinc finger factors
- Sub Familly
- BCL6 factors
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000113916
- UniProt
- P41182
- Genevisible
- P41182
- RefSeq
- NM_001130845
- Aliases
- BCL5; BCL6A; LAZ3; ZBTB27; ZNF51
Datasets Table for BCL6
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| BCL6 | Hep-G2 | ENCODE | Homo sapiens | ENCSR759BDG | 105,449 | |||
| BCL6 | OCI-Ly1 | FA | GEO | Homo sapiens | GSE103125 | 254 | ||
| BCL6 | OCI-Ly1 | UV | GEO | Homo sapiens | GSE103125 | 9,305 | ||
| BCL6 | CD4 | GEO | Homo sapiens | GSE59933 | 33,830 | |||
| BCL6 | OCI-Ly1 | GEO | Homo sapiens | GSE29282 | 80,809 | |||
| BCL6 | OCI-Ly7 | GEO | Homo sapiens | GSE44420 | 10,136 | |||
| BCL6 | B-cell | GERMINAL_CENTER | GEO | Homo sapiens | GSE43350 | 34,017 | ||
| BCL6 | B-cell | GERMINAL_CENTER | GEO | Homo sapiens | GSE68349 | 25,046 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |