ATRX
Information ATRX
- Description
The protein encoded by this gene contains an ATPase/helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations in this gene are associated with X-linked syndromes exhibiting cognitive disabilities as well as alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2017]
- Full Name
ATRX chromatin remodeler
- Source NCBI
ReMap Statistics
- Datasets
- 3
- Biotypes
- 3
- Peaks
- 1,684
- Non-redundant peaks
- 1,658
TF Classification
- Super Class
- Zinc-coordinating DNA-binding domains
- Class
- Other C4 zinc finger-type factors
- Familly
- GATA-type zinc fingers
- Sub Familly
- Single GATA-type zinc-finger
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000085224
- UniProt
- P46100
- Genevisible
- P46100
- RefSeq
- NM_000489
- Aliases
- JMS; MRX52; RAD54; RAD54L; XH2; XNP; ZNF-HX
Datasets Table for ATRX
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ATRX | erythroid | GEO | Homo sapiens | GSE22162 | 1,283 | |||
| ATRX | LAN6 | KOATRX | GEO | Homo sapiens | GSE70920 | 208 | ||
| ATRX | K-562 | KOATRX | GEO | Homo sapiens | GSE70920 | 193 | ||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |