ARNTL
Information ARNTL
- Description
The protein encoded by this gene is a basic helix-loop-helix protein that forms a heterodimer with CLOCK. This heterodimer binds E-box enhancer elements upstream of Period (PER1, PER2, PER3) and Cryptochrome (CRY1, CRY2) genes and activates transcription of these genes. PER and CRY proteins heterodimerize and repress their own transcription by interacting in a feedback loop with CLOCK/ARNTL complexes. Defects in this gene have been linked to infertility, problems with gluconeogenesis and lipogenesis, and altered sleep patterns. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
- Full Name
aryl hydrocarbon receptor nuclear translocator like
- Source NCBI
ReMap Statistics
- Datasets
- 6
- Biotypes
- 1
- Peaks
- 91,038
- Non-redundant peaks
- 77,813
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- PAS domain factors
- Sub Familly
- Arnt-like factors
Source TFClass
External IDs
- JASPAR
- Ensembl
- ENSG00000133794
- UniProt
- O00327
- Genevisible
- O00327
- RefSeq
- NM_001030272
- Aliases
- BMAL1; BMAL1c; JAP3; MOP3; PASD3; TIC; bHLHe5
Datasets Table for ARNTL
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ARNTL | U2OS | GEO | Homo sapiens | GSE44236 | 20,741 | |||
| ARNTL | U2OS | DMOG | GEO | Homo sapiens | GSE85096 | 32,023 | ||
| ARNTL | U2OS | DMSO | GEO | Homo sapiens | GSE85096 | 12,215 | ||
| ARNTL | U2OS | trough_DMOG | GEO | Homo sapiens | GSE85096 | 17,969 | ||
| ARNTL | U2OS | trough_DMSO | GEO | Homo sapiens | GSE85096 | 8,090 | ||
| ARNTL | U2OS | GEO | Homo sapiens | GSE69100 | 279 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |