ARNT
Information ARNT
- Description
This gene encodes a protein containing a basic helix-loop-helix domain and two characteristic PAS domains along with a PAC domain. The encoded protein binds to ligand-bound aryl hydrocarbon receptor and aids in the movement of this complex to the nucleus, where it promotes the expression of genes involved in xenobiotic metabolism. This protein is also a co-factor for transcriptional regulation by hypoxia-inducible factor 1. Chromosomal translocation of this locus with the ETV6 (ets variant 6) gene on chromosome 12 have been described in leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2013]
- Full Name
aryl hydrocarbon receptor nuclear translocator
- Source NCBI
ReMap Statistics
- Datasets
- 11
- Biotypes
- 9
- Peaks
- 566,286
- Non-redundant peaks
- 531,412
TF Classification
- Super Class
- Basic domains
- Class
- Basic helix-loop-helix factors (bHLH)
- Familly
- PAS domain factors
- Sub Familly
- Arnt-like factors
Source TFClass
External IDs
- JASPAR
- MA0259
- Ensembl
- ENSG00000143437
- UniProt
- P27540
- Genevisible
- P27540
- RefSeq
- NM_001197325
- Aliases
- HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; TANGO; bHLHe2
Datasets Table for ARNT
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |
|---|---|---|---|---|---|---|---|---|
| ARNT | GM12878 | ENCODE | Homo sapiens | ENCSR590KEQ | 15,548 | |||
| ARNT | HEK293T | ENCODE | Homo sapiens | ENCSR760UKJ | 1,501 | |||
| ARNT | Hep-G2 | ENCODE | Homo sapiens | ENCSR029IBC | 1,150 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR155KHM | 12,328 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR613NUC | 26,693 | |||
| ARNT | K-562 | ENCODE | Homo sapiens | ENCSR669NFS | 2,130 | |||
| ARNT | RCC10 | GEO | Homo sapiens | GSE101063 | 1,582 | |||
| ARNT | HUVEC-C | GEO | Homo sapiens | GSE89836 | 543 | |||
| ARNT | MCF-7 | GEO | Homo sapiens | GSE41820 | 369,183 | |||
| ARNT | T-47D | HAEGIN2 | GEO | Homo sapiens | GSE59935 | 135,183 | ||
| ARNT | 786-M1A | GEO | Homo sapiens | GSE98012 | 445 | |||
| Target name | Target modification | Ecotype/Strain | Biotype | Biotype modification | Source | Species | Experiment | Peaks |