RELA

Information RELA

Description

NF-kappa-B is a ubiquitous transcription factor involved in several biological processes. It is held in the cytoplasm in an inactive state by specific inhibitors. Upon degradation of the inhibitor, NF-kappa-B moves to the nucleus and activates transcription of specific genes. NF-kappa-B is composed of NFKB1 or NFKB2 bound to either REL, RELA, or RELB. The most abundant form of NF-kappa-B is NFKB1 complexed with the product of this gene, RELA. Four transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

Full Name

RELA proto-oncogene, NF-kB subunit

Source NCBI

ReMap Statistics

Datasets
90
Biotypes
33
Peaks
2,099,450
Non-redundant peaks
956,892

TF Classification

Super Class
Immunoglobulin fold
Class
Rel homology region (RHR) factors
Familly
NF-kappaB-related factors
Sub Familly
NF-kappaB p65 subunit-like factors

Source TFClass

External IDs

JASPAR
MA0107
Ensembl
ENSG00000173039
UniProt
Q04206
Genevisible
Q04206
RefSeq
NM_001145138
Aliases
CMCU; NFKB3; p65

External links
All peaks RELA
Download BED file
Non redundant peaks RELA
Download BED file
SEQUENCES RELA
Download FASTA file
DOWNLOAD All ReMap
Got to catalogue

Datasets Table for RELA

Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks
RELA GM10847 ENCODE Homo sapiens ENCSR000DYM 6,633
RELA GM12878 ENCODE Homo sapiens ENCSR000EAG 24,520
RELA GM12878 ENCODE Homo sapiens ENCSR664POU 24,879
RELA GM12891 ENCODE Homo sapiens ENCSR000EAI 22,513
RELA GM12892 ENCODE Homo sapiens ENCSR000EAN 3,924
RELA GM15510 ENCODE Homo sapiens ENCSR000EAQ 8,989
RELA GM18505 ENCODE Homo sapiens ENCSR000EAW 7,025
RELA GM18526 ENCODE Homo sapiens ENCSR000EBA 7,344
RELA GM18951 ENCODE Homo sapiens ENCSR000EBD 6,538
RELA GM19099 ENCODE Homo sapiens ENCSR000EBI 24,649
RELA GM19193 ENCODE Homo sapiens ENCSR000EBM 4,814
RELA monocyte nopretreatment GEO Homo sapiens GSE100381 147,036
RELA monocyte notreatment GEO Homo sapiens GSE100381 475,795
RELA SW480 0h_TNFa GEO Homo sapiens GSE102796 3,393
RELA SW480 16h_TNFa GEO Homo sapiens GSE102796 37,386
RELA K-562 ENCODE Homo sapiens ENCSR772EEN 11,999
RELA THP-1 eGFP-Pam3csk-0h GEO Homo sapiens GSE103477 1,625
RELA THP-1 eGFP-Pam3csk-4h GEO Homo sapiens GSE103477 19,408
RELA AC16 GEO Homo sapiens GSE51169 1,227
RELA AC16 TNFA GEO Homo sapiens GSE51169 6,816
RELA BJAB GEO Homo sapiens GSE117250 15,432
RELA BJAB 1h-activation GEO Homo sapiens GSE117250 22,076
RELA BJAB 4h-activation GEO Homo sapiens GSE117250 11,374
RELA CD4 TH1_BAY GEO Homo sapiens GSE62482 18,330
RELA CD4 TH1_DMSO GEO Homo sapiens GSE62482 21,695
RELA HDF DMSO GEO Homo sapiens GSE77225 4,573
RELA HDF NUTLIN GEO Homo sapiens GSE77225 10,669
RELA HEK293 TNF-15min GEO Homo sapiens GSE75562 573
RELA HEK293 TNF-1h GEO Homo sapiens GSE75562 27,285
RELA HEK293 TNF-30min GEO Homo sapiens GSE75562 2,720
RELA HEK293 GEO Homo sapiens GSE89017 1,170
RELA HEK293 15min GEO Homo sapiens GSE89017 260
RELA HEK293 30_min GEO Homo sapiens GSE89017 2,134
RELA HEK293 60_min GEO Homo sapiens GSE89017 692
RELA KB GEO Homo sapiens GSE52469 18,957
RELA KB IL GEO Homo sapiens GSE52469 25,747
RELA KB GEO Homo sapiens GSE64223 1
RELA KB 5Z GEO Homo sapiens GSE64223 4,394
RELA KB 5Z_IL GEO Homo sapiens GSE64223 3,943
RELA KB IL GEO Homo sapiens GSE64223 2
RELA KB PHA GEO Homo sapiens GSE64223 1
RELA KB PHA_IL GEO Homo sapiens GSE64223 1
RELA L1236 GEO Homo sapiens GSE63736 612
RELA LNCaP DHT_TNFA GEO Homo sapiens GSE83860 20,451
RELA LNCaP SICTR_TNFA GEO Homo sapiens GSE83860 29,236
RELA LNCaP SIFOXA1_TNFA GEO Homo sapiens GSE83860 37,589
RELA LNCaP TNFA GEO Homo sapiens GSE83860 2,573
RELA SGBS GEO Homo sapiens GSE64233 23,174
RELA SGBS TNF GEO Homo sapiens GSE64233 75,034
RELA U2OS GEO Homo sapiens GSE109996 2,267
RELA U2OS 10Gy_2h_recovery GEO Homo sapiens GSE109996 1,193
RELA 786-O GEO Homo sapiens GSE109953 25,140
RELA 786-O GEO Homo sapiens GSE86092 69,699
RELA Huh-7 IL1 GEO Homo sapiens GSE89212 2,078
RELA HUVEC-C TNF_0M GEO Homo sapiens GSE34500 901
RELA HUVEC-C TNF_30M GEO Homo sapiens GSE34500 29,815
RELA HUVEC-C TNF GEO Homo sapiens GSE43070 7,571
RELA HUVEC-C GEO Homo sapiens GSE53998 295
RELA HUVEC-C TNF GEO Homo sapiens GSE53998 16,746
RELA HUVEC-C TNF_JQ1 GEO Homo sapiens GSE53998 19,548
RELA HUVEC-C Notch1kd_IL1beta GEO Homo sapiens GSE87552 86,678
RELA HUVEC-C Scr GEO Homo sapiens GSE87552 7,123
RELA HUVEC-C Scr_IL1beta GEO Homo sapiens GSE87552 81,614
RELA IMR-90 GEO Homo sapiens GSE43070 803
RELA IMR-90 TNF GEO Homo sapiens GSE43070 22,640
RELA MCF-7 GEO Homo sapiens GSE59530 790
RELA MCF-7 E2 GEO Homo sapiens GSE59530 941
RELA MCF-7 E2_TNF GEO Homo sapiens GSE59530 2,681
RELA MCF-7 TNF GEO Homo sapiens GSE59530 1,572
RELA MCF-7 E2_45m GEO Homo sapiens GSE67295 2,932
RELA MCF-7 IL1b_45m GEO Homo sapiens GSE67295 27,098
RELA MCF-7 TNFa_45m GEO Homo sapiens GSE67295 14,562
RELA MCF-7 Veh GEO Homo sapiens GSE67295 27,874
RELA HeLa-B2 DMSO GEO Homo sapiens GSE24518 3,158
RELA HeLa-B2 GRKD_DMSO GEO Homo sapiens GSE24518 12,452
RELA HeLa-B2 GRKD_TA_TNFA GEO Homo sapiens GSE24518 10,511
RELA HeLa-B2 P65KD_DMSO GEO Homo sapiens GSE24518 7,393
RELA HeLa-B2 P65KD_TA_TNFA GEO Homo sapiens GSE24518 8,413
RELA HeLa-B2 TA GEO Homo sapiens GSE24518 1,358
RELA HeLa-B2 TA_TNFA GEO Homo sapiens GSE24518 18,284
RELA HeLa-B2 TNFA GEO Homo sapiens GSE24518 21,829
RELA HAEC GEO Homo sapiens GSE89970 31,745
RELA HAEC IL1b_4h GEO Homo sapiens GSE89970 58,062
RELA HAEC TNFa_4h GEO Homo sapiens GSE89970 77,150
RELA Detroit-562 LPS GEO Homo sapiens GSE91018 29,303
RELA Detroit-562 Pam2CSK4 GEO Homo sapiens GSE91018 24,053
RELA Detroit-562 Poly-I GEO Homo sapiens GSE91018 40,025
RELA Detroit-562 TNFa GEO Homo sapiens GSE91018 38,351
RELA Detroit-562 tri-DAP GEO Homo sapiens GSE91018 23,352
RELA 786-M1A GEO Homo sapiens GSE98012 14,239
Target name Target modification Ecotype/Strain Biotype Biotype modification Source Species Experiment Peaks

ReMap is a database of transcriptional regulators peaks derived from curated ChIP-seq, ChIP-exo, DAP-seq experiments in Human and Thaliana.

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The ReMap catalogues (2020, 2018, 2015) are under CC BY-NC 4.0 international license, while ReMapEnrich, remap-pipeline under GNU GPLv3 licence.

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This work was granted access to the HPC resources of Aix-Marseille Université financed by the project Equip@Meso (ANR-10-EQPX-29-01) of the program "Investissements d’Avenir" supervised by the Agence Nationale de la Recherche.